10319305
Description
Quiz by Michael Jardine, updated more than 1 year ago
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Created by Michael Jardine
over 6 years ago
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Question 1
Question
What is the difference between cell growth and cell proliferation?
Answer
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Cell growth = increase in ONE cell's mass/size; Cell proliferation = increase in cell numbers.
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Cell growth = increase in cell numbers; Cell proliferation = increase in ONE cell's mass/size.
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No meaningful distinction. (/ distinction without substantial difference) (/ fuck all)
Question 2
Question
Which of the following is true?
Answer
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Control of cell proliferation is intrinsically linked to cell growth.
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Control of cell growth is intrinsically linked to cell proliferation.
Question 3
Question
The order of the rough phases of the cell cycle are as follows:
G1 > [blank_start]_____[blank_end] > [blank_start]_____[blank_end] > [blank_start]_____[blank_end] > [blank_start]_____[blank_end] (then back to G1 again)
Answer
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S
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G2
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M
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Cytokinesis
Question 4
Question
G1 phase stands for, and involves, what?
Answer
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Growth phase
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Gap phase
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Cell growth
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Monitoring
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Mitosis
Question 5
Question
G2 phase stands for, and involves, what?
Answer
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Growth phase
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Gap phase
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Cell growth
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Monitoring
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Mitosis
Question 6
Question
S phase stands for, and involves, what?
Answer
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DNA synthesis
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Selectivity
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Cell growth
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Mitosis
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Stretching
Question 7
Question
M phase stands for, and involves, what?
Answer
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Mitosis
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Meiosis
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Monitoring
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DNA synthesis
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Cell division
Question 8
Question
Cdks (Cyclin-Dependent KinaseS) are regulated by:
Answer
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Cyclins
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Phosphorylation
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Both of the above
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[none of the above]
Question 9
Question
Mitogens are:
Answer
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Things that stimulate cell division (e.g. hormones, cytokines).
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Stimulate migration.
Question 10
Question
Disordered signaling in cancer.
Many cancer-critical genes (oncogenes or tumour-suppressor genes) regulate cell growth and proliferation.
e.g. a mutation may lead to independence from mitogen-dependence.
Acquiring the ability to synthesise mitogens (resulting in autocrine stimulation) is one way this can happen. Some examples of this are:
Answer
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PDGF, TGFα - glioblastomas & osteosarcoma
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EGF-R/erbB (epidermal growth factor receptor); HER2 (human epidermal growth factor receptor)
Question 11
Question
Disordered signaling in cancer.
Many cancer-critical genes (oncogenes or tumour-suppressor genes) regulate cell growth and proliferation.
e.g. a mutation may lead to independence from mitogen-dependence.
Constitutive expression of their receptors (resulting in increased sensitivity?) is one way this can happen. Some examples of this are:
Answer
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PDGF, TGFα - glioblastomas & osteosarcoma
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EGF-R/erbB (epidermal growth factor receptor); HER2 (human epidermal growth factor receptor)
Question 12
Question
HER2 (Human Epidermal growth factor Receptor) mutations are present in:
Answer
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Overexpressed in breast cancer.
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Overexpressed in stomach, brain, and breast cancer.
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Abnormally present in glioblastomas and osteosarcoma.
Question 13
Question
EGF-R / erbB (Epidermal Growth Factor Receptor) and cancer...
Answer
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Up-regulated in stomach, brain, and breast cancer.
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Up-regulated in breast cancer.
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Abnormally present in gliobastomas & osteosarcoma.
Question 14
Question
True or false: Mitogens [usually?] act through the ras/raf/ERK cascade.
Answer
- True
- False
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