10320480
Description
Quiz by Michael Jardine, updated more than 1 year ago
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Created by Michael Jardine
about 7 years ago
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Question 1
Question
True or false:
Cells which have entered senescence have a large, flattened morphology "like poached eggs".
Answer
- True
- False
Question 2
Question
Mutations in p53 and/or Rb can lead to:
Answer
-
Bypassing senescence and crisis.
-
Bypassing senescence and entering crisis.
-
Entering crisis.
-
[none of the above]
Question 3
Question
Cells in "crisis" have which of the following traits?
(select all that apply)
Answer
-
Massive cell death
-
Reduced cell death
-
Increased genomic stability
-
Genomic instability
Question 4
Question
The Hayflick limit is:
Answer
-
The number of divisions a cell can undergo before entering senescence.
-
(not this one)
Question 5
Question
Telomeres shorten by ~[blank_start]_____[blank_end] bp with each round of cell division.
Answer
-
5 - 15
-
50 - 150
-
500 - 1,500
-
5,000 - 15,000
-
130 - 210
-
2,000 - 40,000
Question 6
Question
There are two [main?] telomere maintenance mechanisms. These are Telomerase and ALT.
What does ALT stand for?
[blank_start]_____[blank_end]
Answer
-
Alternative Lengthening of Telomeres
Question 7
Question
Which [non-cancerous] cell type does NOT have shortening telomeres during replication?
Answer
-
Germ line cells
-
Stem cells
-
Cardiomyocytes
Question 8
Question
Telomerase is:
Answer
-
An enzyme
-
A protein
-
A molecule
Question 9
Question
Which telomere maintenance mechanism is used in the majority of cancers?
Answer
-
Telomerase
-
ALT
Question 10
Question
Telomerase can be detected using which of the following methods:
(select all that apply)
Answer
-
TRAP (Telomere Repeat Amplification Protocol) assay
-
TRF (Terminal Restriction Fragment) assay
-
APBs (ALT-associated PML Bodies)
-
C-circle assay
-
Movement of the telomere tag
Question 11
Question
ALT can be detected using which of the following methods?
(select all that apply)
Answer
-
TRAP (Telomere Repeat Amplification Protocol) assay
-
TRF (Terminal Restriction Fragment) assay
-
APBs (ALT-associated PML Bodies)
-
C-circle assay
-
Movement of the telomere tag
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