PHSI3011 01-2 Cardiac excitation-contraction coupling 1 - Channels, exchangers, pumps

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PHSI3011 01-2 Cardiac excitation-contraction coupling 1 - Channels, exchangers, pumps
Michael Jardine
Quiz by Michael Jardine, updated more than 1 year ago
Michael Jardine
Created by Michael Jardine over 6 years ago
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Resource summary

Question 1

Question
Which of the following is NOT a type of Calcium channel?
Answer
  • G-type
  • L-type
  • N-type
  • T-type

Question 2

Question
An L-type Calcium channel has how many subunits? (each controlled by a separate gene)
Answer
  • 2
  • 3
  • 4
  • 5
  • 6
  • 7
  • 8

Question 3

Question
An L-type Calcium channel is highly selective for Calcium, but is also somewhat permeable to Sodium and Potassium.
Answer
  • True
  • False

Question 4

Question
During diastole, the Na/Ca exchanger and the SR Ca pump both move Ca. Which way around?
Answer
  • Na/Ca exchanger will pull Ca IN to the myoplasm; the SR Ca pump will pump Ca back INTO the SR.
  • Na/Ca exchanger will pull Ca IN to the myoplasm; the SR Ca pump will pump Ca back OUT of the SR.
  • Na/Ca exchanger will push Ca OUT from the myoplasm; the SR Ca pump will pump Ca back INTO the SR.
  • Na/Ca exchanger will push Ca OUT from the myoplasm; the SR Ca pump will pump Ca back OUT of the SR.

Question 5

Question
The longitudinal SR contains a high concentrations of proteins acting as an ATP-dependent Ca pump - returning Ca from the myoplasm to the SR lumen (to help terminate contraction). These proteins are called SERCA. What does SERCA stand for? [blank_start]S[blank_end] [blank_start]E[blank_end] [blank_start]R[blank_end] [blank_start]C[blank_end] [blank_start]A[blank_end]
Answer
  • Sarco
  • Sarcoplasmic
  • Endo
  • Endoplasmic
  • [plasmic] Reticulum
  • [plasmic] Ryanodine
  • Calcium
  • Concentration
  • Activation
  • Activator
  • Adjustment
  • ATPase

Question 6

Question
The role that Phospholamban plays in regulation of the SR Ca pump is:
Answer
  • Inhibitory; cancelled when phosphorylated.
  • Inhibitory; reinforced when phosphorylated.
  • Permissive; cancelled when phosphorylated.
  • Permissive; reinforced when phosphorylated.
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