Question 1
Question
In normal RBC destruction, globin is recycled and Fe is broken down
Question 2
Question
In Intravascular Haemolytic Anaemia, cells are lysed in the blood vessels
Question 3
Question
Why is Intravascular H.A so dangerous?
Answer
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Hb dimers form in the blood and block the kidneys
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R.B.C fragments block capillaries
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R.B.C's aggregate and block capillaries
Question 4
Question
Renal failure and Heamoglobinurea are caused by...
Answer
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Intravascular
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Extravascular
Question 5
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What is implicated in Extravascular Haemolytic Anaemia
Answer
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The spleen
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The bone marrow
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The liver
Question 6
Question
In Extravascular, macrophage Fc receptors bind to the RBC's Ig's
Question 7
Question
Once bound, what happens to RBC's in Haemolytic Anaemia
Question 8
Question
If small portions of RBC membrane is removed, what happens?
Question 9
Question
Loss of RBC's leads to low glucose in the spleen, which leads to...
Answer
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Inc haemolysis
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Fatigue
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Inc risk of diabetes
Question 10
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Reticuloctosis- inc presence of reticulocytes
Question 11
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What causes reticulocytosis?
Answer
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The body trying to replace lost R.B.C's but can't keep up production
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The damaged R.B.Cs degenerate into reticulocytes
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The lymphocytes attack R.B.Cs, making them degenerate into reticulocytes
Question 12
Question
In Drug Induced Haemolytic Anaemia, what happens?
Answer
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Drug induced antibodies cross react
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Drug specific antibodies cross react
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Drugs cause R.B.C's to aggregate
Question 13
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Haemolytic Anaemias can be caused by physical stress....
Question 14
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March Haemoglobinurea is damge to RBC's in small foot bones due to prolonged marching/running
Question 15
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Infections can cause H.A by altering R.B.C morphology
Question 16
Question
What's the difference between Immune and Autoimmune Haemolytic Anaemia?
Question 17
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In some cases, an RBC transfusion can lead to degredation of the original RBC's
Question 18
Question
Name two types of Inherited Haemolytic Anaemia
Answer
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Sickel Cell Anaemia
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Thalassaemia
Question 19
Question
Hereditary Spherocytosis is caused by an abnormal membrane causing Spherical R.B.C's