Disorders of the Neuromuscular Junction & Muscle

Description

Disorders of the Neuromuscular Junction & Muscle given on 26/09/2018
Matthew Coulson
Quiz by Matthew Coulson, updated more than 1 year ago
Matthew Coulson
Created by Matthew Coulson about 6 years ago
145
1

Resource summary

Question 1

Question
Lambert Eaton Myasthenic Syndrome is a autoimmune disease whereby antibodies attack and destroy ...
Answer
  • Presynaptic Vesicles
  • Presynaptic Calcium Channels
  • Postsynaptic Receptors

Question 2

Question
Lambert Eaton Myasthenic Syndrome typically causes muscle weakness in which parts of the body?
Answer
  • Distal limbs (arms and legs)
  • Proximal limbs (arms and legs)
  • Typically legs only
  • Typically arms only

Question 3

Question
60% of patients with Lambert-Eaton Myasthenic Syndrome have an underlying malignancy. Which malignancy does it most commonly present with?
Answer
  • Small cell lung cancer
  • Adenocarcinoma of the lung
  • Squamous cell lung cancer
  • Large cell lung cancer
  • Breast cancer
  • Renal cancer

Question 4

Question
What is the most common disorder of the neuromuscular junction?
Answer
  • Lambert-Eaton Myasthenic Syndrome
  • Myasthenia Gravis
  • Neuromyotonia
  • Congenital Myasthenia

Question 5

Question
Myasthenia Gravis is an autoimmune condition whereby the body develops autoantibodies against [blank_start]acetylcholine[blank_end] receptors
Answer
  • acetylcholine

Question 6

Question
Symptoms of Myasthenia Gravis only tend to start once ACh receptors are reduced to [blank_start]30[blank_end]% of normal
Answer
  • 30
  • 60
  • 5

Question 7

Question
Which of the following structures is also known to play a part in Myasthenia Gravis?
Answer
  • Thymus
  • Bone Marrow
  • Thalamus
  • Pituitary Gland
  • Adrenal Gland

Question 8

Question
Males tend to typically present with Myasthenia Gravis in their 30s whereas woman tend to present in their 60s-70s
Answer
  • True
  • False

Question 9

Question
The difference between Myasthenia Gravis and Lambert-Eaton Myasthenic Syndrome is that ...
Answer
  • Myasthenia Gravis tends to present mostly in the proximal legs, but not the arms.
  • Myasthenia Gravis tends to present mostly in the proximal arms, but not the legs.

Question 10

Question
Whilst Myasthenia Gravis typically presents with proximal weakness of the proximal leg muscles, it also tends to cause weakness in which of the following?
Answer
  • Extraocular muscles
  • Facial muscles
  • Carpal muscles
  • Tarsal muscles
  • Abdominal muscles
  • Investing fascia muscles

Question 11

Question
The initial therapy for most patients with myasthenia gravis is an oral acetylcholinesterase inhibitor, usually [blank_start]pyridostigmine[blank_end]
Answer
  • Pyridostigmine
  • Physostigmine
  • Neostigmine
  • Rivastigmine

Question 12

Question
Aminoglycoside antibiotics impair neuromuscular transmission and can cause clinically significant muscle weakness, resulting in respiratory depression in myasthenia gravis patients. Therefore, which of the following medications should be avoided in such patients?
Answer
  • Gentamicin
  • Ceftriaxone
  • Amoxicillin
  • Metronidazole
  • Doxycycline

Question 13

Question
Inability to relax voluntary muscle after vigorous effort is known as [blank_start]myotonia[blank_end].
Answer
  • myotonia

Question 14

Question
Rhabdomyolysis releases high amounts of [blank_start]Myoglobin[blank_end] into the plasma thus causing Acute Kidney Injury (AKI)
Answer
  • Myoglobin
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