445668
Description
Quiz by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
over 10 years ago
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Question 1
Question
Which of the following can cause double strand breaks in the DNA?
Answer
-
Ionising radiation
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Meiosis
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Chemicals
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DNA replication errors
Question 2
Question
What are Chromosome Fragile Sites?
Answer
-
Sites where double strand breaks are likely to occur
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Sites that can be easily split accidentally by protein machinery
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Sites that are likely to warp during heat shock
Question 3
Question
Chromosome fragile sites are thought to be caused by difficulties during meiosis
Answer
- True
- False
Question 4
Question
What does NHEJ stand for?
Answer
-
Non-homologous end joining
-
Non-homologous editing joints
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Non-heterodimeric end joints
Question 5
Question
What are the requirements for NHEJ?
Answer
-
Double strand breaks
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Single strand breaks
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T-T lesions
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DNA ligase 4
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DNA ligase 2
Question 6
Question
The repair process of NHEJ will join any 2 free ends together, regardless of homology
Answer
- True
- False
Question 7
Question
An error in NHEJ can lead to translocation between which chromosomes, forming what type of chromosome fusion?
Answer
-
Philadelphia chromosome
-
Inverted chromosome
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8 &12
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9 & 22
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13 & 21
Question 8
Question
The repair process of Homologous Recombination relies on what?
Answer
-
That the damaged sequence in the sister chromatid is intact
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That the damaged sequence in the homologous chromosome is intact
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That the damaged sequence in the other allele is intact
Question 9
Question
What is required for an error in Homologous Recombination?
Answer
-
A faulty alignment of the two chromosomes
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A faulty alignment of the two chromatids
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Due to inversions
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Due to translocations
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Due to repeats
Question 10
Answer
-
NHEJ
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Homologous Recombination
Question 11
Question
A fault in Homologus Recombination can lead to alleles being lost
Answer
- True
- False
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