444041
Description
Quiz by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
over 10 years ago
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Question 1
Question
The complimentation test is used to find out if mutations are allelic or non allelic
Answer
- True
- False
Question 2
Question
In what circumstances will a Complimentation Test give a false result?
Answer
-
When the mutation is recessive
-
When the mutation is dominant
-
When the mutated gene is part of a complex
-
Where proteins form multimers
Question 3
Question
Genotypes M1 & M2 are bred together, and a Wild Type result is obtained- are the mutations allelic
Answer
-
No- as the presentation of a wild type phenotypes shows there is at least one dominant wild type allele for each gene
-
Yes- The two mutations on the same allele are able to compliment each other sufficiently to produce a wild type phenotype
Question 4
Question
If M3 and M2 are bred together and they present as M2, what does this tell us about the mutation's location?
Answer
-
They are on the same allele- there is no dominant wild type allele to mask their activity
-
They are on separate alleles, but M2 has a far greater effect than previously thought
Question 5
Question
According to the above table, which mutations are allelic
Answer
-
M9 & M4
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M8 & M6
-
M2
-
All of the above
Question 6
Question
A Complimentation Test can be fooled if the mutant protein can form a functioning heterodimer with the wild type protein
Answer
- True
- False
Question 7
Question
One gene is said to be epistatic to another if...
Answer
-
The presence of a double mutant exhibits the phenotype of the mutant gene
-
The presence of the wild type masks the phenotype of the mutant gene
-
A genes expression causes a change in the expression of another gene further down the pathway
Question 8
Question
Where are epistatic genes usually found in substrate dependent pathways?
Answer
-
Upstream
-
Downstream
Question 9
Question
A substrate dependent pathway is a series of positive and negative regulators that act on one another of the final product
Answer
- True
- False
Question 10
Answer
- True
- False
Question 11
Question
Why should null alleles be used for epistatic analysis (i.e how to find out the order of gene function in a pathway)
Answer
-
The masking of alleles downstream becomes obvious
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They are easier to make than hypomorphic alleles
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They can be used for both Substrate Dependent and Switch pathways
Question 12
Question
How do we identify that the pathway effected by the (epistatic) mutation is a Switch Regulatory pathway?
Answer
-
If the mutation prevents the production of the final product
-
If the phenotype of a double mutant is different to the phenotype of either single mutant
Question 13
Question
The Rif1 & Rif2 strains are both causes lengthened telomeres, as shown in the diagram. Based on the Rif1/Rif2 double mutation, which of the two availible pathways (shown) is likely to be the one used?
Image:
Rif1 (image/png)
Answer
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Pathway A
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Pathway B
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