Apoptosis

Description

Year 2 Quiz on Apoptosis, created by gina_evans0312 on 03/12/2013.
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Quiz by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312 over 10 years ago
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Resource summary

Question 1

Question
What is the main difference between apoptosis and necrosis?
Answer
  • In necrosis release of cell contents is controlled In apoptosis it's not
  • In apoptosis release of cell contents is controlled In necrosis it's not

Question 2

Question
What protein condenses during apoptosis
Answer
  • Chromatin
  • Actin
  • Myosin

Question 3

Question
What form are caspases usually found in?
Answer
  • Inactive, with their DED domain tails intact
  • Active, with their DED domain tails intact
  • Inactive, with their DED domain tails removed
  • Active, with their DED domain tails removed

Question 4

Question
What is required for caspase activation?
Answer
  • Addition of a DED domain tail
  • Removal of the DED domain tail

Question 5

Question
What are the roles of the 2 main caspases?
Answer
  • 3 is the initation 8 does most damage
  • 8 is the initiator 3 does most damage

Question 6

Question
Which of the following are survival/protector proteins that inhibit caspase activation?
Answer
  • BAX, BAD, PUMA
  • Bci-2, Mcl1, A1

Question 7

Question
What is required for ligand acitvated apoptosis?
Answer
  • For the receptors to contain DED domains
  • For the receptors to be bound to caspases
  • For the receptors to be expressed only in certain areas of the cell membrane

Question 8

Question
What protein inhibits the activation of apoptic receptors?
Answer
  • Flp
  • Flr
  • Fld

Question 9

Question
Name an apoptic receptor
Answer
  • Fas
  • Far
  • Fam

Question 10

Question
How does the receptor activate caspase 8?
Answer
  • By recruiting it and cleaving off the DED domain
  • By recruiting it and adding a DED domain

Question 11

Question
Name the two methods caspase 8 uses to destroy the cell
Answer
  • Activation of Caspase 3
  • Deactivation of Caspase 3
  • Damage to mitochondria, which releases Cyt. C

Question 12

Question
What does mitochondrial damage do to Casp 9?
Answer
  • Activates it
  • Deactivates it

Question 13

Question
What happens when essential growth factors are withdrawn from the cell?
Answer
  • PI3K cannot activate
  • PKB cannot activate
  • Casp 8 cannot activate

Question 14

Question
How does PKB inhibit apoptosis?
Answer
  • Releases Bad from Blc-2
  • Releases Blc2 from Bad

Question 15

Question
Identify methods which cells can use to evade apoptosis
Answer
  • Decreased Fas receptor expression
  • Inc Blc2 & decrease bax/bad expression
  • Loss of Casp 8
  • Increased Flp expression
  • Soluble fas to causes apoptosis in t-cells
  • Large amounts of Fas ligand produced to kill t-cells
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