409783
Description
Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
over 10 years ago
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| Question | Answer |
| p85 | Regulatory domain of Phosphatidynosityl-3-Kinase |
| p110 | Catalytic domain of Phosphatidynosityl-3-Kinase |
| Phosphatidynosityl-3-Kinase | Family of lipid kinases recruited to active tyrosine kinase |
| Ras-GTP | Required for full PI-3-K activation |
| Carbon of phosphatydinositol phosphorylated by PI-3-K | 3rd |
| PTEN | Reverses action of PI-3-Kinase |
| Phosphorylated membrane lipids | PKB docking site |
| No of PKB domains | 3 |
| PKB-Plecstrin Homology Domain | Binds molecule to phosphorylated lipid & recruits signalling molecules to membrane |
| Binding to membrane | Required for activation |
| PDK1 & PDK2 | Phosphorylate & activate PKB |
| mTOR | Massive lipid/protein kinase complex that binds to PKB |
| Role of mTOR | Part of DNA damage repair family |
| mTOR activates... | Protein synthesis & cell growth |
| PDK1 & 2 are .... active | Permanently |
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