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Oncogene Classification

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Year 2 Quiz on Oncogene Classification, created by gina_evans0312 on 02/12/2013.
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Quiz by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312 about 11 years ago
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Resource summary

Question 1

Question
Give an example of a Class 1 Onocgene- Growth Factors
Answer
  • Erb-B
  • ERK
  • Sis

Question 2

Question
What is the function of the sis protein?
Answer
  • Forms a PDGF(Beta) chain
  • Forms a IPGF(Beta) chain
  • Forms a IGF1(Beta) chain

Question 3

Question
Name the two ways a cell can access extra Growth factor
Answer
  • A virus produces extra growth factor as it replicates
  • A cell begins to make it's own growth factor through growth factor genes
  • A cell begins to steal growth factor from surrounding cells

Question 4

Question
Name the Class 2 oncogene
Answer
  • Growth Factor Receptors
  • Growth Factors
  • Intracellular Transducers

Question 5

Question
Name a Class 2 Oncogene
Answer
  • Erb-B
  • Sis
  • IGF1
  • TGFB

Question 6

Question
How does Erb-b become oncogene?
Answer
  • ....bind permanently to their ligand and so become constitutionally active
  • ... no longer need their ligand to activate become constitutionally active
  • ...form a constitutionally active dimer
  • ...no longer needs to dimerise to activate

Question 7

Question
What is erb-b?
Answer
  • Family of tyrosine kinase receptors that bind to EGF
  • Family of tyrosine kinase receptors that bind to TGFB
  • Family of tyrosine kinase receptors that bind to IGF1

Question 8

Question
Similarly, in 'neu' receptors, what replaces the Valine to make a constantly active receptor?
Answer
  • Glutamine
  • Glutamic Acid
  • Glutamate

Question 9

Question
What is Herceptin?
Answer
  • A tyrosine kinase agonist?
  • A humanised monoclonal antibody
  • An Erb-B agonist

Question 10

Question
What does Herceptin bind to?
Answer
  • Erb B
  • HER2
  • Tyrosine Kinase

Question 11

Question
Name the 3rd Class of Oncogenes
Answer
  • Growth factors
  • Transcription factors
  • Intracellular transducers

Question 12

Question
Which of the following is a class 3A oncogoene?
Answer
  • Erb-B
  • Src
  • c-myc

Question 13

Question
What determines the types of src tyrosine kinase present in the cell?
Answer
  • The cell type
  • The stage of the cell cycle
  • The age of the cycle

Question 14

Question
What is the role of Cellular Transducers
Answer
  • Relay information to the nucleus to regulate gene transcription
  • Relay information to the ribosomes to regulate protein synthesis
  • Relay information to the Golgi Complex to regulate cell receptor production

Question 15

Question
What allows Src to stick to the cytoplasm
Answer
  • A modified lipid
  • A modified glycoprotein
  • A modified phospholipid

Question 16

Question
Name the substance that anchors src to the membrane
Answer
  • Myristate
  • Palmatite
  • Acetylate

Question 17

Question
What holds src kinase shut in its inactive form?
Answer
  • A phosphate on Tyr 527 in its inactive form & the SH2 domain
  • A phosphate on Tyr 527 in its inactive form & the SH3 domain
  • A phosphate on Tyr 537 in its inactive form & the SH2 domain

Question 18

Question
Put the following domains of Src in order A- Unique Domain B- Sh2 Domain C-Catalytic Domain D- Regulatory Domain E- SH3
Answer
  • A-B-E-C-D
  • A-B-C-D-E
  • A-B-D-E-C

Question 19

Question
What is the focus of an SH3 domain?
Answer
  • Protein- protein interaction
  • Protein- phosphotyrosine interaction
  • Protein-phosphoserine interactoin

Question 20

Question
What sequence is favored by SH3 domains?
Answer
  • Proline rich; Pro-X-X-Pro
  • Histadine rich; His-X-X-His
  • Gycine rich; Gy-X-X-Gly

Question 21

Question
What is required for Src to activate?
Answer
  • For the protein to be at the membrane
  • For the protein to be cytosolic
  • The SH2 domain then releases the regulatory domain and binds to P-Tyrosine Kinase

Question 22

Question
What happens to the regulatory domain once the SH2 domain has released it?
Answer
  • It's dephosphorylated by a phosphatase at the membrane at Tyr 527
  • It's phosphorylated by the tyrosine kinase at Tyr 527
  • Nothing

Question 23

Question
What tyrosine residue is phosphorylated by tyrosine kinase?
Answer
  • 416 on the activation lip
  • 417 on the activation lip
  • 418 on the activation lip

Question 24

Question
What is the most common oncogene form of src?
Answer
  • Loss of regulatory domain (last 19 amino acids) so it cannot be phosphorylated
  • Loss of SH2 domain so it cannot bind to regulatory domain when phosphorylated
  • Modified lipid binds permanently to the membrane

Question 25

Question
Ras is the name of a small family of what?
Answer
  • GTPase's
  • ATPase's
  • UTPase's

Question 26

Question
What process localyses Ras to the membrane?
Answer
  • Acetylation
  • Methylation
  • Farnesylation

Question 27

Question
What is sos?
Answer
  • A GAP
  • A GEF
  • A GDI

Question 28

Question
Where does GTP bind to ras?
Answer
  • At the C and N terminus
  • In the centre

Question 29

Question
What is the purpose of the discrete domain of Ras
Answer
  • To bind GTP
  • To bind GDP
  • To bind downstream molecules

Question 30

Question
What are GDI's?
Answer
  • Guanine Nucleotide Disassociation Inhibitors
  • Guanine Nucleotide Dimerisation Inhibitors
  • Gunanine Nucleotide Decamerisation Inhibitors

Question 31

Question
What is the purpose of a GDI and how it controlled?
Answer
  • By molecules recruited to the tyrosine receptor
  • Bind to Ras and prevent activation
  • Bind to Ras and prevent de-activation

Question 32

Question
In which domains can a single mutation turn Ras into an oncogene?
Answer
  • L1
  • L2
  • L3
  • L4
  • L5

Question 33

Question
What is the role of GRB2
Answer
  • Binds Ras to membrane
  • Binds Ras to TK receptor
  • Binds Ras to Raf

Question 34

Question
How many SH2 domains does GRB2 have?
Answer
  • 2- both in the middle
  • 2- one on each end
  • 1 in the middle
  • 1 at the N terminus
  • 1 at the C terminus

Question 35

Question
What protein is used by Src to activate Ras?
Answer
  • Srk
  • Sch
  • Shc

Question 36

Question
How does src phosphorylate the protein that activates Ras?
Answer
  • Binds to SH3 domain
  • Binds to SH2 domain
  • Binds to discrete domain

Question 37

Question
Name the two proteins for which phosphorylated Shc has a very high affinity?
Answer
  • Ras
  • Sos
  • GRB2
  • GDI

Question 38

Question
Name the 4th class of oncogenes
Answer
  • Growth factors
  • Cellular Transporters
  • Growth Factor Receptors
  • Transcription factors

Question 39

Question
Name a class 4 oncogene
Answer
  • Src
  • Ras
  • Jun

Question 40

Question
Name the part of c-jun that causes dimerisation
Answer
  • Leu Zipper
  • His zipper
  • Ala zipper

Question 41

Question
Where is the unique sequence of c-jun and what is it's role?
Answer
  • Near the center
  • Near the c-terminus
  • Near the n-terminus
  • Defines family member
  • Determines where in the DNA c-jun binds

Question 42

Question
Put the domains of C-jun in the correct order A-Leu Zipper B- Delta Domain C-Transcription Domain D- Unique Domain E- DNA Binding Domain
Answer
  • D-B-C-E-A
  • D-E-A-B-C
  • C-A-D-B-E

Question 43

Question
How does C-jun function
Answer
  • As a homodimer
  • As a heterodimer
  • As both

Question 44

Question
What is the first step of c-jun homodimer activation?
Answer
  • Dephosphorylation by PKC
  • Phosphorylation by JNK (ERK parallel protein)

Question 45

Question
What is the second step of c-jun homodimer activation?
Answer
  • Dephosphorylation by PKB
  • Phosphorylation by JNK

Question 46

Question
What part(s) of c-jun is lost to make it an oncogene?
Answer
  • Unique sequence
  • Delta Domain
  • Leu zipper

Question 47

Question
Name a protein likely to form a heterodimer with c-jun
Answer
  • AFK
  • AFT
  • AFR

Question 48

Question
What tends to be transcribed by the first c-jun heterodimer to form?
Answer
  • c-jun
  • AFK
  • Fos

Question 49

Question
What is the second protein to heterodimerise with c-jun?
Answer
  • Fos
  • Fas
  • Fis

Question 50

Question
What is the name of the second heterodimer formed by c-jun?
Answer
  • AP1
  • Ap2
  • AP

Question 51

Question
What is required for Fos transcription?
Answer
  • TCF/AFK to be activated by ERK
  • AFK to be activated by ERK
  • TCF to be activated by ERK

Question 52

Question
What sequences does AP1 bind to?
Answer
  • TGAC
  • GTAC
  • GGAC

Question 53

Question
What is transcribed by AP1?
Answer
  • Transcription factors
  • Ribosomal proteins
  • Growth factors

Question 54

Question
Is Cyclin D1 transcribed by Jun?
Answer
  • Yes
  • No

Question 55

Question
What happens if the signal activating AP1 persists for 30 mins?
Answer
  • It's activity is increased further by phosphorylation
  • It's activity is increased further by methylation
  • By Jnk/Erk

Question 56

Question
What transcribes C-Myc?
Answer
  • API
  • Fos
  • c-Jun

Question 57

Question
How long is the half life of C-myc?
Answer
  • 5-10 mins
  • 5-10 seconds
  • 3-5 mins

Question 58

Question
What does Myc bind to in order to interact with E-Box sequences?
Answer
  • Max
  • Mad
  • Mac

Question 59

Question
Why is Ubiquitin ligase transcribed by c-myc?
Answer
  • Halts protein turnover & allows protein levels to build up
  • Increases protein turnover so only new proteins are involved in the cell cycle

Question 60

Question
In normal cells, which of the following is in excess, and why?
Answer
  • Max, so the dimer only forms when Myc levels are signaled to rise
  • Mic, so the dimer only forms when Max levels are signalled to rise

Question 61

Question
How are Max homodimers inhibitory?
Answer
  • They block jun transcription sites
  • They block jun expression promoters
  • They block myc expression promoters

Question 62

Question
What is different in tumor cells from normal cells (concerning myc/max levels)?
Answer
  • Myc levels are always higher than Max
  • Max levels are always higher than myc
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