PHSI3012 10-2 Disorders of Lipid Metabolism #2 (T3L2)

Cholesterol is a 26-Carbon sterol lipid that’s synthesised through a complex 37-step process. It composes [blank_start]__________[blank_end] of cell membranes. Circulating cholesterol arises from the diet as well as from [blank_start]__________[blank_end] synthesis. It circulates mostly as Cholesterol Ester (cholesterol + FA).

Familial Hypercholesterolaemia is a family of pathologies that range from heterozygous to homozygous. It’s characterised by [blank_start]__________[blank_end] [blank_start]__________[blank_end] levels. Caused by a loss of LDL-R.

Lysosomal Storage Disease (aka Niemann-Pick disease type C) is a collection of ~50 rare inherited metabolic pathologies. Its hallmark is defective lysosomal function. It’s characterised by [blank_start]__________[blank_end] [blank_start]__________[blank_end] in the lysosome due to the loss of function of NPC1 and/or NPC2.

The highly proliferative nature of cancer cells means they have increased metabolic requirements, especially of which two things?

In cancer, metabolism changes. De Novo Cholesterol [blank_start]__________[blank_end] [blank_start]__________[blank_end]; De Novo Lipid [blank_start]__________[blank_end] [blank_start]__________[blank_end].

Prostate cancer growth is [primarily?] driven by [blank_start]__________[blank_end]. It’s a [blank_start]__________[blank_end] metabolism cancer and is greatly dependent on [blank_start]__________[blank_end].

CRPC = ??

Gene Expression of Steroidogenic Enzymes is [blank_start]__________[blank_end] in CRPC.