PHSI3011 11-2 Liver in Metabolic Homeostasis

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PHSI3011 11-2 Liver in Metabolic Homeostasis
Michael Jardine
Quiz by Michael Jardine, updated more than 1 year ago
Michael Jardine
Created by Michael Jardine over 6 years ago
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Resource summary

Question 1

Question
Glycolysis turns [blank_start]__________[blank_end] into [blank_start]__________[blank_end].
Answer
  • Glucose-6-P
  • Pyruvate
  • Glucose
  • Glycogen
  • Lactate
  • Glycerol
  • Amino Acids

Question 2

Question
Glycogenesis turns [blank_start]__________[blank_end] into [blank_start]__________[blank_end].
Answer
  • Glucose-6-P
  • Pyruvate
  • Lactate
  • Glucose
  • Glycerol
  • Amino Acids
  • Glycogen

Question 3

Question
Gluconeogenesis turns [blank_start]__________[blank_end] into [blank_start]__________[blank_end].
Answer
  • Pyruvate
  • Glucose-6-P
  • Glucose
  • Glycogen
  • Glucagon

Question 4

Question
Glycogenolysis turns [blank_start]__________[blank_end] into [blank_start]__________[blank_end].
Answer
  • Glycogen
  • Glucose-6-P
  • Pyruvate
  • Glucose
  • Lactate
  • Glycerol
  • Glucagon
  • Amino Acids

Question 5

Question
The three rate-limiting steps of Gluconeogenesis are:
Answer
  • Glucose 6-Phosphatase
  • Fructose 1,6-bisphosphatase
  • PEP carboxykinase
  • Pyruvate kinase
  • Phosphofructokinase-1
  • Hexokinase

Question 6

Question
The three rate-limiting steps of Glycolysis are:
Answer
  • Glucose 6-Phosphatase
  • Fructose 1,6-bisphosphatase
  • PEP carboxykinase
  • Pyruvate kinase
  • Phosphofructokinase-1
  • Hexokinase

Question 7

Question
Which one is which: Glycolysis vs Gluconeogenesis
Answer
  • Gluconeogenesis
  • Glycolysis

Question 8

Question
Put the three rate-limiting steps (of each side) in the right places.
Answer
  • Glucose 6-Phosphatase
  • Fructose 1,6-bisphosphatase
  • PEP carboxykinase
  • Hexokinase
  • Phosphofructokinase-1
  • Pyruvate kinase

Question 9

Question
Does insulin STIMULATE or SUPPRESS glucose disposal and glycogen&lipid synthesis?
Answer
  • Stimulate
  • Suppress

Question 10

Question
Does insulin STIMULATE or SUPPRESS glucose production and VLDL secretion?
Answer
  • Stimulate
  • Suppress

Question 11

Question
What’s a LIRKO?
Answer
  • Liver-specific Insulin Receptor KnockOut mouse
  • Loss of Insulin Receptor KnockOut mouse
  • Liver-specific Insulin Receptor Knockout Organism
  • Loss of Insulin Receptor Knockout Organism

Question 12

Question
What results in a LIRKO in regards to blood&serum glucose levels?
Answer
  • Blood increase; serum increase
  • Blood increase; serum decrease
  • Blood decrease; serum increase
  • Blood decrease; serum decrease

Question 13

Question
Loss of PTEN expression in the liver results in increased Liver Triglyceride levels. What’s PTEN?
Answer
  • Phosphatase and TENsin homolog
  • Phosphatase and TENsin ligand
  • Phosphatase and TENsin binding factor
  • Phosphatase and TENsin lipase

Question 14

Question
Glucose is taken up in a GLUT2-dependent manner. It’s then stored as [blank_start]__________[blank_end] until blood glucose levels drop.
Answer
  • Glycogen
  • Glucose 6-Phosphate
  • Pyruvate
  • Glucagon
  • Glycerol

Question 15

Question
The liver contributes to the homeostasis of circulating levels of which?
Answer
  • Fatty Acids
  • Cholesterol

Question 16

Question
The liver is the main clearance tissue for removal of Fatty Acids from circulation, then repackages them in what?
Answer
  • VLDL-TAG
  • LDL-TAG
  • HDL-TAG
  • Chylomicron-TAG

Question 17

Question
Stages of Lipoprotein and FA uptake: [blank_start]_____[blank_end] – [blank_start]__________[blank_end] resides on endothelial cells to hydrolyse VLDL-TAG to FAs for uptake
Answer
  • Stage 1
  • Stage 2
  • Stage 3
  • Hepatic lipase (and Lipoprotein lipase)
  • Periphery
  • Liver

Question 18

Question
Stages of Lipoprotein and FA uptake: [blank_start]_____[blank_end] – [blank_start]__________[blank_end]: TAG-rich VLDL interacts with VLDL-R, enters lysosomal pathway for hydrolysis and TAG synthesis.
Answer
  • Stage 1
  • Stage 2
  • Stage 3
  • Hepatic lipase (and Lipoprotein lipase)
  • Periphery
  • Liver

Question 19

Question
Stages of Lipoprotein and FA uptake: [blank_start]_____[blank_end] – [blank_start]__________[blank_end]: VLDL-remnants interact with a range of receptors for endocytosis.
Answer
  • Stage 1
  • Stage 2
  • Stage 3
  • Hepatic lipase (and Lipoprotein lipase)
  • Periphery
  • Liver

Question 20

Question
Fatty Acid metabolism. The major pathways are: De novo lipogenesis: [blank_start]__________[blank_end] TriAcylGlycerol metabolism: [blank_start]__________[blank_end] β-Oxidation: [blank_start]__________[blank_end]
Answer
  • Synthesis of fatty acids from non-lipid
  • Esterification, Lipoprotein and Lipolysi
  • FA-CoA >> acetyl-CoA

Question 21

Question
Fatty Acid Metabolism: loss of Lipolysis-Stimulated Receptor (LSR) expression does what?
Answer
  • Increase in Serum TriGlyceride levels
  • Decrease in Liver TriGlyceride levels
  • Decrease in Serum TriGlyceride levels
  • Increase in Liver TriGlyceride levels

Question 22

Question
Loss of CD36 in the liver leads to [blank_start]__________[blank_end] Plasma FA levels. Plasma FAs [blank_start]__________[blank_end] LPL activity. Therefore loss of CD36 [blank_start]__________[blank_end] Chylomicron/VLDL-TAG hydrolysis (breakdown). …Leading to [blank_start]__________[blank_end] of TAG in the circulation.
Answer
  • Increased
  • Unaffected
  • Reduced
  • Inhibit
  • Stimulate
  • Reduces
  • Increases
  • Accumulation
  • Shortage

Question 23

Question
True or false: The Hepatokine ILGF stands for Insulin-Like Growth Factor.
Answer
  • True
  • False

Question 24

Question
What's this bit called?
Answer
  • Glycolysis
  • Glycogenesis
  • Gluconeogenesis
  • Glycogenolysis

Question 25

Question
What's this bit called?
Answer
  • Glycolysis
  • Glycogenesis
  • Gluconeogenesis
  • Glycogenolysis

Question 26

Question
What's this bit called?
Answer
  • Glycolysis
  • Glycogenesis
  • Gluconeogenesis
  • Glycogenolysis

Question 27

Question
What's this bit called?
Answer
  • Glycolysis
  • Glycogenesis
  • Gluconeogenesis
  • Glycogenolysis

Question 28

Question
What could be here?
Answer
  • Pyruvate
  • Glycogen

Question 29

Question
What could be here?
Answer
  • Pyruvate
  • Glycogen

Question 30

Question
What could be here?
Answer
  • Pyruvate
  • Glycogen

Question 31

Question
What could be here?
Answer
  • Pyruvate
  • Glycogen
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