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Immune System

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Science Board Review (Microbiology) Mind Map on Immune System, created by dsandoval on 29/02/2016.
dsandoval
Mind Map by dsandoval, updated more than 1 year ago
dsandoval
Created by dsandoval over 8 years ago
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Resource summary

Immune System
  1. Cell-mediated Immunity
    1. T-cells
      1. defense against infection
        1. like mycobacterium tuberculosis
          1. viral/fungal
          2. Allergic response
            1. Ex: poison oak
          3. Antibody-mediated (Humoral) Immunity
            1. B-Cells
              1. defense against infection
                1. opsonizes bacteria
                  1. neutralizes toxins/viruses
                  2. allergic response ex: Hay fever
                    1. autoimmunity
                    2. SPECIFICITY OF IMMUNE RESPONSE
                      1. Involves: recognition, activation, and response
                        1. may be natural (innate)/acquired (adaptive)
                        2. NATURAL IMMUNITY
                          1. Non-specific
                            1. not acquired from previous exposure
                              1. Does not improve after exposure
                                1. NO memory
                                  1. Host defenses
                                    1. Skin, mucous membranes
                                      1. Natural killer cells
                                        1. Phagocytosis
                                          1. Inflammation
                                        2. ACUIRED IMMUNITY
                                          1. after exposure
                                            1. improves w/ repeated exposure
                                              1. Mediated by antibodies and T-cells
                                                1. Long-term memory
                                                  1. Can be passive/active
                                                  2. ANTIGENS
                                                    1. Foreigness: Non-self
                                                      1. Dosage, route and timing of exposure
                                                      2. CELLS OF IMMUNE SYSTEM
                                                        1. Made up of Leukocytes
                                                          1. Granulocytes
                                                            1. Neutrophils, eosinophils, basophils
                                                            2. Lymphocytes
                                                              1. T-cells, B-cells, natural killer cells
                                                              2. Monocytes
                                                                1. precursor to macrophage
                                                                2. Dendritic Cells
                                                                  1. APC's
                                                                    1. key regulator
                                                                    2. Produced in bone marrow
                                                                    3. T Cells
                                                                      1. 65-80% of lymphocytes
                                                                        1. Arise in bone marrow
                                                                          1. T-cytotoxic cell
                                                                            1. directly kill and attack
                                                                            2. CD 4 T cell
                                                                              1. produce cytokines, stimulate macrophages, NK cells, dendritic cell and other T-cell
                                                                            3. B Cells
                                                                              1. produce antibodies
                                                                                1. Are APC's
                                                                                  1. Can form memory cells
                                                                                  2. MACROPHAGES
                                                                                    1. 3 main funcitons
                                                                                      1. Phagocytosis
                                                                                        1. Antigen transportation
                                                                                          1. Cytokine production
                                                                                        2. Nk cells
                                                                                          1. kill viruses/tumor infected cells
                                                                                            1. Non-specific
                                                                                              1. kill w/o antibody
                                                                                              2. PMN's
                                                                                                1. most numerous WBC 60%
                                                                                                  1. capable of phagocytosis
                                                                                                    1. 1st line of defense
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