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11977453
Acquired Immunity: Cell-med and Humoral
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User has deleted their subject information Mind Map on Acquired Immunity: Cell-med and Humoral, created by Deleted user on 23/01/2018.
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Mind Map by Deleted user, updated more than 1 year ago
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Plymouth Med
over 6 years ago
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Plymouth Med
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Resource summary
Acquired Immunity: Cell-med and Humoral
Antigen Presenting Cell arrives at Lymphnode
APC
MHC II
Antigen
TCR
immature CD4+ T helper cells
Differentiation Maturation
Mature CD4+ THI cells
Bring over CD8+ T cells
mature CD8+ T cells
mature CD8+ T cells
TCR
IL 2
INF-gamma
further macrophage activation
production of IL-1
helps with epithelial rolling
releases reactive oxygen species
IL 2
INF-gamma
MHC I
A
mature CD8+ T cells
Infected Cell
MHC I
A
Release of Cytotoxic Granule
Granzyme
Perforin
Punches Holes in cell's exterior
Enzyme that messes up cell's interior
mature CD8+ T cells
Activation of "Death Sign
FAS-FAS Ligand
Apoptosis
Cell Mediated Response
Humoral Response
APC
MHC II
A
TCR
immature CD4+ T helper cells
Differentiation Maturation
Mature CD4+ TH II Cells
IL 5
B cell maturation
Plasma B cells
Undergoes Class Switch
Early stages of infection
mainly IgM
Innate antibody
Very nonspecific
Pentamer
BCR
IgD
IgM
Can accept antigen and trigger release of chemokine same way APC will
EARLY STAGES: IgM
IgM will act as a BCR and trigger
OR
cause class switch
b/c chemokine cause clonal selection and clonal expansion
APC will trigger
Later stages of infection
mainly IgG
specific antibody
Transplacental
Clumps and neutralizes pathogens
produces the antibodies
Memory B cells
stores antibodies in case of second exposure
Memory T cells
IL 10
inhibits maturation and proliferation after a while
IL 4
Clonal Selection
Clonal Expansion
cannot happen without cell mediated
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