DNA Repair Defects & Cancer Therapy


Year 2 Flashcards on DNA Repair Defects & Cancer Therapy, created by gina_evans0312 on 01/12/2013.
Flashcards by gina_evans0312, updated more than 1 year ago
Created by gina_evans0312 over 10 years ago

Resource summary

Question Answer
Xeroderma Pigmentosum Inability to repair pyrimidine dimers caused by UV damage
2 Options for DNA damaged cells Apoptosis, or replication of faulty DNA
Primary Site treatment Surgical Removal
Mesastised Cell Treatment Chemo/radiotherapy
Cytostatic Prevents cell proliferation
Cytotoxic Causes cell destruction
Aim of Cancer treatments Maximum effect on tumor with minimum side effects
Theraputic Window- Cancer therapies sit at the top of the curve
Cell Culture- Primary Cells Essentially normal cells
Cell Culture- Crisis Outside of the body, even in a good environment, most of the cells cannot survive and will die
Cell Culture- Established Cell Line Cells have modified enough to divide indefinitely, but are otherwise normal
Maximum Tolerated Effect Greatest strength of treatment possible without killing the patient
Cell Culture- Transformed Cells Cells are bascially cancerous, but are non-mobile
Cell Culture- Tumerogenic Cells are now mobile and able to metastise
Show full summary Hide full summary


Bowel (Colorectal) cancer
Mark George
Drugs used to treat lung cancer & staging system
Alyssa B
Molecular cell biology of cancer
Alyssa B
Cancer- Primary Events
Cell Line Traits
Morphology of Tumerogenic Cells
Metastasis & Cancer Viruses
Oncology Final MCQs 1- 5th Year PMU
Med Student
Head, Neck and Back 2nd Sem- Anatomy 2nd Year- PMU
Med Student
Respiratory System 2nd Year PMU Anatomy
Med Student
Respiratory System Year 2/
Sole C