DNA Repair Defects & Cancer Therapy

Question	Answer
Xeroderma Pigmentosum	Inability to repair pyrimidine dimers caused by UV damage
2 Options for DNA damaged cells	Apoptosis, or replication of faulty DNA
Primary Site treatment	Surgical Removal
Mesastised Cell Treatment	Chemo/radiotherapy
Cytostatic	Prevents cell proliferation
Cytotoxic	Causes cell destruction
Aim of Cancer treatments	Maximum effect on tumor with minimum side effects
Image: Theraputic_Window (image/png)	Theraputic Window- Cancer therapies sit at the top of the curve
Cell Culture- Primary Cells	Essentially normal cells
Cell Culture- Crisis	Outside of the body, even in a good environment, most of the cells cannot survive and will die
Cell Culture- Established Cell Line	Cells have modified enough to divide indefinitely, but are otherwise normal
Maximum Tolerated Effect	Greatest strength of treatment possible without killing the patient
Cell Culture- Transformed Cells	Cells are bascially cancerous, but are non-mobile
Cell Culture- Tumerogenic	Cells are now mobile and able to metastise

Resource summary

	Created by gina_evans0312 over 10 years ago