Benign Prostatic Hyperplasia

Description

Pathophysiology, medications, CMs, Diagnostics
Mark George
Flashcards by Mark George, updated more than 1 year ago
Mark George
Created by Mark George over 10 years ago
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Resource summary

Question Answer
BPH Patho Static Component Proliferation of Glandular Epithelium (alterations of testosterone, estrogen, DHT)
BPH Patho Dynamic component Increase in prostatic smooth muscle tone linked to altered activity of PICs (possibly contributes to increased prostate contractility)
BPH Pharmacology Finasteride 5Alpha Reductase inhibitor Blocks conversion of testosterone into DHT Altered libido / Impotence
BPH Pharmacology Tamsulosin Alpha1a adrenoceptor antagonist blocks prostatic smooth muscle receptors :- decreases Ca++ availability (decreased prostate contractility) Postural hypotension / GIT
BPH diagnostics DRE (digital rectal exam) Physical exam determines the state and size of the external surface of the prostate gland
BPH Diagnostics PSA Blood test that measures the level of specific antigen produced by both benign and malignant prostate tissue
BPH Clinical Manifestations (Obstructive) proLONGed voiding. WEAK urinary stream. INCOMPLETE emptying. abdominal STRAINing. posturination DRIBBLE.
BPH Clinical manifestations (Irritative) nocturia bladder PAIN URGENT urination incontinence
BPH Clinical manifestations (Ureter obstruction) Bladder/kidney INFECTION acute urinary RETENTION RENAL INSUFFICIENcy HAEMATURIA
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