Antigen Presentation

Description

Year 2 Quiz on Antigen Presentation, created by gina_evans0312 on 13/03/2014.
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Quiz by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312 over 10 years ago
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Resource summary

Question 1

Question
B Cells recognise native antigens, T cells recognise processed antigens
Answer
  • True
  • False

Question 2

Question
Which of the following are NOT professional antigen presenting cells?
Answer
  • Neutrophils
  • Macrophages
  • Dendritic cells

Question 3

Question
CD8 T-cells recognise which MHC complex?
Answer
  • MHCI
  • MHCII

Question 4

Question
CD4 is for the detection of virally infected cells
Answer
  • True
  • False

Question 5

Question
CD4 cells recognise MHCII, which uses which Antigen processing system?
Answer
  • Endosomal
  • Endogenous
  • Endomal

Question 6

Question
Cells with MHCI present using the endogenous AP system
Answer
  • True
  • False

Question 7

Question
T- cells cannot recognise soluble, native antigens
Answer
  • True
  • False

Question 8

Question
Put the following steps in the correct order- A (Antigen-MHC Complex Formation), B (Uptake), C (Presentation) and D (Degredation
Answer
  • B-D-A-C
  • A-B-D-C
  • A-C-B-D

Question 9

Question
Which of the following definitions is incorrect?
Answer
  • Uptake- picking up of the antigen from surrounding fluid
  • Degredation- total digestion of the antigen
  • Presentation- movement of the complex to the cell surface

Question 10

Question
Endosomal Pathway- What is it for?
Answer
  • Processing of extracellular antigens picked up by antigen presenting cells
  • Processing of cytosolic viral antigens

Question 11

Question
Endosomal Pathway- Uses the MHCI complex
Answer
  • True
  • False

Question 12

Question
Endosomal Pathway- The extracellular antigen is picked up by phagocytosis
Answer
  • True
  • False

Question 13

Question
Endosomal Pathway- How is picking up of the antigen mediated?
Answer
  • Receptor mediated
  • Compliment mediated
  • Hormone mediated

Question 14

Question
Endosomal Pathway- The antigen containing endosome only binds to the MCHII containing endosome after partial digestion
Answer
  • True
  • False

Question 15

Question
Endosomal Pathway- How is the active site of MHCII covered in the cell?
Answer
  • Covered by an invariant 'cap'
  • The two parts are connect by a subunit that must be removed
  • Receptor surface is bound to the endosome envelope

Question 16

Question
Endosomal Pathway- The cover of the MHC complex is called a CLIP
Answer
  • True
  • False

Question 17

Question
Endosomal Pathway- How is the processed antigen added to the MHCII complex?
Answer
  • Acessory proteins swap the CLIP for the peptide when the two vesicles fuse
  • Acessory proteins remove the MHCII from the envelope when the two vesicles fuse
  • Acessory proteins remove the subunit connecting the two halves when the two vesicles fuse

Question 18

Question
Endogenous Pathway- Main use is for what?
Answer
  • Viral antigen processing
  • Professional pesentation of antigens

Question 19

Question
Endogenous Pathway uses MHCII
Answer
  • True
  • False

Question 20

Question
Endogenous Pathway- How are cytosolic antigens processed?
Answer
  • By the TCR
  • By MHCI
  • By cytosolic proteases

Question 21

Question
Endogenous Pathway- Digested peptides are moved into the Golgi by what?
Answer
  • Transporter Associated with Antigen Processing (TAP 1&2)
  • Transporter Associated with Antigen Digestion (TAD 1&2)
  • Transporter Associated with Antigen Presentation (TAP 1&2)

Question 22

Question
In the Golgi the processed peptide is bound to MHCI and they complex is loaded into a vesicle for transport to the cell membrane
Answer
  • True
  • False
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