Antigens Recognition

Question	Answer
PAMP's	Pathogen Associated Molecular Patterns
Role of PAMP's	Vital to metabolic processes of most antigens and so occur in all of them (with some variation)
PRR's	Pattern Recognition Receptors
Role of PRR's	Recognise PAMP's - broad specificity due to PAMP variation
Antibodies on B- Cells	Either membrane bound or secreted (known as immunoglobulins)
Specificty of B-Cells	High- specific for one antigen
T Cell Receptors	Membrane bound Ig's specific to T cells (different shape to B-Cell antibodies)
Epitopes	Part of antigen recognised by Ab's - can be continuous or discontinuous
Domains	Basic units of Ib's
L Chain Domains	2- 1 variable, 1 constant
H chain Domains	1 Variable, 3-4 constant
Image: Antibody_Fab (image/jpg)	Fab Domain- can rotate & bend to aid Ag binding
Image: Antibody_FaC (image/jpg)	Fac- can 'wag' to aid binding
3 Hypervariable Regions	Present in the variable domains, which form CDR loops
CDR	Complimentarity Determining Regions
Role of CDR	Some will bind to specific antigen (though not necessarily all- some are just for recogniton, not binding)
Role of Ig's- Opsonisation	Coating of pathogen so phagocytes can recognise Fc's
Role of Ig's- Compliment Stabilisation	Allows compliment to Opsonise pathogen & activates further compliment cascade
Role of Ig's- Neutralisation	Binds to pathogen preventing invasion & blocking action of the toxin

Resource summary

	Created by gina_evans0312 almost 11 years ago