514671
Question 1
Question
Which of the following is NOT a major mast cell mediator?
Answer
-
Heparin
-
Arachadonic acid
-
Platelet activating factor
-
Neutrophilic chemotactic factor
-
Lymphocytic chemotactic factor
-
Serine proteases
Question 2
Question
Which of the following are effects of histamine? Check all that apply.
Answer
-
Stimulates nitric oxide production (potent vasodilator)
-
Enhances leukocyte chemotaxis
-
Produces arachadonic acid metabolites
-
Stimulates smooth muscle contraction (bronchi, small intestines, pulmonary vasoconstriction)
-
Causes decreased vascular permeability
Question 3
Question
Leukotrienes are metabolites of arachadonic acid that are potent bronchoconstrictors.
Answer
- True
- False
Question 4
Question
Which of the following pairings is INCORRECT?
Answer
-
Serine proteases- destroy nearby cells and activate complement
-
Kinins- stimulate pain receptors
-
Cytokines- regulate storage and release of vasoactive mediators
-
Heparin- acts as anticoagulant
Question 5
Question
Generally, the onset of anaphylaxis is not related to severity of signs.
Answer
- True
- False
Question 6
Question
Localized anaphylaxis has evidence of generalized mediator release restricted to cutaneous findings alone. Which of the following is NOT one of these findings?
Answer
-
Erythema
-
Pruritis
-
Urticaria
-
Angioedema
-
These are all appropriate cutaneous findings, Karah. Get it together!
Question 7
Question
Which of the following are true regarding epinephrine for systemic anaphylaxis? Check all that apply.
Answer
-
Blocks effects of mediators
-
Reduces further mast cell degranulation
-
Increases cardiac output
-
Promotes bronhoconstriction
-
Peripheral vasodilation
-
IV dose of 1 mg/ml concentration is 0.05-0.1 ml/10 lbs
Question 8
Question
When treating anaphylaxis with crystalloid IV fluids it is important that systolic blood pressure is maintained at >80 mmHg.
Answer
- True
- False
Question 9
Question
Which of the following is the anti-inflammatory dose of dexamethasone SP for treatment of anaphylaxis?
Answer
-
0.1-0.2 mg/kg IV
-
0.5-1 mg/kg IV
-
0.1-0.2 mg/kg IM
-
0.5-1 mg/kg IM
Question 10
Question
The IM dose of diphenhydramine for systemic anaphylaxis is 1-2 mg/kg.
Answer
- True
- False
Question 11
Question
What drug can we use to manage persistent bradycardia with systemic anaphylaxis?
Answer
-
Atropine, 0.02-0.04 mg/kg IV, IM
-
Atropine, 0.2-0.4 mg/kg IV, IM
-
Dobutamine, 5-10 mcg/kg/min IV (constant rate infusion)
-
Dobutamine, 0.5-1 mcg/kg/min IV (constant rate infusion)
Question 12
Question
Aminophylline/theophyylline is a bronchodilator given IM or IV (slowly) at 4-8 mg/kg.
Answer
- True
- False
Question 13
Question
What is the dose for oral diphenhydramine for treatment of localized anaphylaxis?
Answer
-
1 mg/lb q 8 hrs until all signs are clear
-
1 mg/kg q 8 hrs until all signs are clear
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