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Fibrinolysis

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Haematology and Anatomy (Coagulation) Quiz on Fibrinolysis, created by gina_evans0312 on 10/01/2014.
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Quiz by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312 over 10 years ago
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Resource summary

Question 1

Question
The vascular endothelium protects platelets from subendothelial aggregating substances i.e. collagen
Answer
  • True
  • False

Question 2

Question
Vasoconstriction around injured site helps coagulation how?
Answer
  • Reduced blood flow decreases pressure and loss of blood
  • Reduced blood flow brings coagulation factors into tissue contact more readily
  • Reduced blood flow decreases wall diameter, decreasing size of breach

Question 3

Question
Why is Fibrinolysis necessary?
Answer
  • It prevents inappropriate extension of the fibrin plug
  • Prevents clotting from damaging nearby cell
  • Prevents clotting in case of infected blood

Question 4

Question
To prevent inappropriate prevention of coagulation, where are coagulation inhibitors limited to?
Answer
  • Intact endothelium
  • Breached endothelium
  • Free flowing blood

Question 5

Question
Inhibitors are triggered by late products of coagulation
Answer
  • True
  • False

Question 6

Question
What is inhibited by the Tissue Factor Pathway Inhibitor?
Answer
  • FX reversibly
  • FX permanently
  • FVII
  • FV

Question 7

Question
Anthithrombin deactivates several enzymes of the coagulation system
Answer
  • True
  • False

Question 8

Question
Protein S & C work the same way
Answer
  • True
  • False

Question 9

Question
The Protein C pathway is initiated by what?
Answer
  • Thrombin
  • Antithrombomodulin
  • Antithrombin

Question 10

Question
Thrombomodulin works in the free flowing blood
Answer
  • True
  • False

Question 11

Question
Both thrombin and thrombomodulin work on the endothelial cell surface
Answer
  • True
  • False

Question 12

Question
What is the role of thrombomodulin?
Answer
  • Conversion of Thrombin to Antithrombin
  • Conversion of Thrombin to a Coagulation Inhibitor
  • Removal of platelets

Question 13

Question
Excess thrombin binds to thrombomodulin on intact cells, which allows it to be altered
Answer
  • True
  • False

Question 14

Question
Protein C acts as an anticoagulant by degrading Factors
Answer
  • V
  • VIII

Question 15

Question
Protein C needs Mg in order to function
Answer
  • True
  • False

Question 16

Question
Which of the following support Protein C activity?
Answer
  • Protein S
  • Inactive F V
  • Active F V

Question 17

Question
60% of patients with thrombophilia have a
Answer
  • Factor II deficiency
  • Protein C deficiency
  • Protein S deficiency

Question 18

Question
VTE = Venous Thromboembolism
Answer
  • True
  • False

Question 19

Question
What is thrombosis?
Answer
  • An increased liklihood of spontaneous clotting
  • An inability to form blood clots

Question 20

Question
Name the risk factors for thrombophilia
Answer
  • Alteration in blood components i.e. pregnancy
  • Circulatory stasis i.e. venous problems
  • Artificial surfaces i.e. a STENT

Question 21

Question
VTE occurs when blood coagulation overwhelms fibrogenlysis/anticoagulant mechanisms
Answer
  • True
  • False

Question 22

Question
Thrombophilia is linked to Lupus Anticoagulant Syndrome
Answer
  • True
  • False

Question 23

Question
Name some examples where Anticoagulation therapy is necessarry
Answer
  • Patient with a myocardial infarction (MI)
  • Patients with Lupus/APS
  • Deep Vein Thrombosis/ Primary Embolism

Question 24

Question
How is Heparin administered?
Answer
  • Intravenously
  • Subcutaneously
  • Ingestion

Question 25

Question
How does Heparin work?
Answer
  • Increases action of Antithrombin
  • Increases Protein C activity
  • Increases degredation of platelets

Question 26

Question
Why is Low Molecular Weight Heparin better?
Answer
  • 100% bioavalibility
  • Longer half life
  • Less frequent osteoporosis

Question 27

Question
Dabigatran is only used in cases of Atrial Fibrilation
Answer
  • True
  • False

Question 28

Question
Dabigatran is a FX inhibitor, Rivaroxabin is a thrombin inhibitor
Answer
  • True
  • False

Question 29

Question
Warfarin works how?
Answer
  • Directly inhibits thrombin
  • Inhibits Vit K metabolism
  • Lyses platelets

Question 30

Question
Without Vitamin K, why is coagulation so much slower?
Answer
  • Non carboxylated factors cannot bind to Ca2+
  • Non carboxylated factors cannot bind to phosphorylated
  • Non carboxylated factors cannot be inhibited

Question 31

Question
Warfarin is used when all four clotting factors are low
Answer
  • True
  • False

Question 32

Question
What is the leading dose of Warfarin?
Answer
  • 6mg for 3 days
  • 3mg for 6 days

Question 33

Question
What test is used to monitor warfarin activity?
Answer
  • Prethrombin time
  • Activated Partial Thromboplastin Time
  • Fibrin Assay

Question 34

Question
What is the reference for Prethrombin Time?
Answer
  • Standard reference thromboplastin
  • Potency is ISI- International Sensitivity Index
  • Standard reference antithrombin

Question 35

Question
INR = Prethrombin Time/ Mean Normal Prethrombin Time
Answer
  • True
  • False

Question 36

Question
Match the dangerous INR ranges- A= (2-3) B= (3-4)
Answer
  • A= Prosthetic Heart Valves B = DVT
  • A = DVT B = Prosthetic Heart Valves

Question 37

Question
When using Warfarin, stop if the INR <2 for two consecutive days
Answer
  • True
  • False
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