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Leukaemia

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Haematology and Anatomy (Leukocytes) Quiz on Leukaemia, created by gina_evans0312 on 09/01/2014.
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Quiz by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312 over 10 years ago
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Resource summary

Question 1

Question
Define leukamia
Answer
  • Neoplastic proliferation of haemopeoietic or lymphoid cells
  • Neoplastic proliferation of lymphoid cells
  • Neoplastic proliferation of bone marrow

Question 2

Question
In acute leukaemia, abnormality occurs in mature cells
Answer
  • True
  • False

Question 3

Question
Acute leukaemia is described as a block in differentiation
Answer
  • True
  • False

Question 4

Question
Acute leukaemia is caused by acute proliferation of...
Answer
  • Myeloblasts
  • Lymphoblasts
  • Both (rare)
  • Both (most common)

Question 5

Question
What are the symptoms of chronic leukaemia?
Answer
  • No block in differentiation
  • Block in differentiation
  • Low proliferation
  • High proliferation

Question 6

Question
Acute leukaemia is recognised by a certain type of cell being up to 50% of bone marrow cells?
Answer
  • Blasts
  • Reticulocytes
  • Lympocytes

Question 7

Question
In A.L, there are often reticulocytes in the peripheral blood
Answer
  • True
  • False

Question 8

Question
Leukaemia is caused by clonal proliferation from a single cell
Answer
  • True
  • False

Question 9

Question
How can you (sometimes) differentiate between a myeloblast and a lymphoblast?
Answer
  • Myeloblasts have auer rods
  • Lymphoblasts have auer rods
  • Myeloblasts have a large, pale nucleus
  • Lymphoblasts have a large, pale nucleus

Question 10

Question
MUD stands for
Answer
  • Matched Unrelated Donor
  • Myeloblast Unknown Death
  • Myeloblasts Under Duress

Question 11

Question
Remission - no disease in the blood
Answer
  • True
  • False

Question 12

Question
Why use the Minimal Residual Disease (MUD)?
Answer
  • Assess chances at relapse/need for further treatment
  • Assess effectiveness of drug
  • Prevent remission

Question 13

Question
BMT - Bone Marrow Transplant
Answer
  • True
  • False

Question 14

Question
B Cell Acute Lymphoblastic Leukaemia has a poor prognosis for children but a good one for adults
Answer
  • True
  • False

Question 15

Question
Which of the following is has the poorer prognosis
Answer
  • Acute T-Cell Precursor Lymphoblastic
  • Acute B-Cell Precursor Lymphoblastic

Question 16

Question
What is found in cytogenetic testing of ALL?
Answer
  • Hyperploidy
  • Aneuploidy
  • Nullosomy

Question 17

Question
Which of the following are found in ALL cytochemistry?
Answer
  • MPX/SB are neg
  • MPX/SB are pos
  • PAS block pos
  • PAS block neg

Question 18

Question
Which of the following are found in Immunophenotyping for ALL?
Answer
  • CD19
  • CD7
  • CD10

Question 19

Question
What is true of AML?
Answer
  • Inc WBC
  • Dec RBC
  • Dec Plateles
  • Inc RBC
  • Inc Platelets

Question 20

Question
AML means there is no normal cells
Answer
  • True
  • False

Question 21

Question
What markers are used in Flow Cytometry to identify AML?
Answer
  • CD13
  • CD33
  • CD12
  • CD4

Question 22

Question
AML is more common in adult women
Answer
  • True
  • False

Question 23

Question
When is AML called 'De Novo'
Answer
  • When it occurs for the first time
  • If it occurs secondary to other malignancies
  • If it never relapses

Question 24

Question
Which of the following is common in AML (as opposed to ALL)
Answer
  • CNS leukaemia
  • Lymph, spleen and gum problems
  • Lymphodenopathy

Question 25

Question
Match up the following- A = Fatigue, B= Fever/Infections, C= Spontaneous Bruising 1 = Low Platelets 2= Low Hb 3 = Low WBC
Answer
  • A2, B3, C1
  • A1, B2, C3
  • A3 B2 C1

Question 26

Question
CML- accumulation of mature myeloid cells
Answer
  • True
  • False

Question 27

Question
Genetic anomalies in CML occur low down where they effect cells
Answer
  • True
  • False

Question 28

Question
What happens in 95% of cases to cause AML?
Answer
  • Chromosome 22 shortens
  • Linking BCR & ABL genes together
  • Chromosome 22 inverts
  • Chromosome 22 lengthens

Question 29

Question
In indentifying CML, immunophenotyping is useless
Answer
  • True
  • False

Question 30

Question
CML is more common in adult men
Answer
  • True
  • False

Question 31

Question
What is the WBC in CML?
Answer
  • >50 x 10^9/l
  • <30 x 10^9/l
  • >75 x 10^9/l

Question 32

Question
What will be found in a CML bone marrow sample?
Answer
  • Bone marrow is hypercellular
  • Bone marrow is hypocellular
  • Myeloid cells are present at all developmental stages
  • Inc Neutraphil Alkaline Phosphatase
  • Red Neutraphil Alkaline Phosphatase

Question 33

Question
Glivec stops CML cells dividing, but is expensive
Answer
  • True
  • False

Question 34

Question
CLL- Neoplastic proliferation of mature looking lymphocytes
Answer
  • True
  • False

Question 35

Question
What ususally happens in CML?
Answer
  • Lymphoids form masses in the bone marrow, spleen and lymph nodes
  • Lymphoids lyse and release contents as they are made poorly
  • Lymphs begin attacking body cells

Question 36

Question
In CLL, the lymph population can be over 300x the normal
Answer
  • True
  • False

Question 37

Question
What are smear cells?
Answer
  • Cells that rupture during a smear
  • Cells so malleable they look like smudges
  • Cells so deformed they form masses, which look like smears

Question 38

Question
In CLL, the bone marrow is <25% lymphocytes
Answer
  • True
  • False

Question 39

Question
What does immunophenotyping in CLL tell us?
Answer
  • Clonality
  • Which lymph cells they are
  • The markers

Question 40

Question
CLL is more common in old men
Answer
  • True
  • False
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