454649
Description
Quiz by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
almost 11 years ago
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Question 1
Question
What does genetic mapping rely on?
Answer
-
Inheritence phenotypes
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Polymorphic Markers
Question 2
Question
How is the tracing of inheritence phenotypes done?
Answer
-
Genetic markers i.e. SNP's
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Allele complimentation
-
Meiotic Tests
Question 3
Question
1cM =
Answer
-
1% recombination
-
10% recombination
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1kB
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10kB
Question 4
Question
How are physical maps made?
Answer
-
Design markers that overlap along the genome
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Orientation of homologous chromosomes
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Allele studies
Question 5
Question
Physical maps must be made of physically isolated parts of the genome
Answer
- True
- False
Question 6
Question
A genetic marker acts as a reference point in a linkage study
Answer
- True
- False
Question 7
Question
Genes are usually used as markers in non-human studies. Why can they not be used in humans?
Answer
-
Human genes are more unstable
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Human genes vary too much
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Human genes are more highly conserved
Question 8
Question
What is the preferred form of marker in humans?
Answer
-
Polymorphic introns
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Polymorphic Exons
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SNP's
Question 9
Question
More polymorphic DNA= less useful
Answer
- True
- False
Question 10
Question
Homozygotes are more useful in genetic mapping than heterozygotes
Answer
- True
- False
Question 11
Question
How must markers be placed along the chromosome?
Answer
-
Evenly spaced
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As lightly as possibly
-
As densely as possible
Question 12
Question
The aim it to combine genetic and physical maps
Answer
- True
- False
Question 13
Question
Once you have a marker with a high linkage to a disease/trait, how do you use the physical map?
Answer
-
Find the marker and look for genes very close to it
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Find the suspect gene and look for markers very close to it
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Find the marker and look for genes as far away as possible
Question 14
Question
Which of the following are evenly distributed?
Answer
-
SNP's
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Minisatellites
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Microsatellites
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RFLP's
Question 15
Question
Microsatellites are highly polymorphic
Answer
- True
- False
Question 16
Question
Which of the following are most useful as markers?
Answer
-
RFLP's
-
Minisatellites
-
Microsetellites
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SNP's
Question 17
Question
There are two alleles (usually) for RFLP's
Answer
- True
- False
Question 18
Question
How are minisatellites typed?
Answer
-
Southern Hybridisation
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Gel Electrophoresis
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PCR
Question 19
Question
There are more than 10^10 SNP's in the human genome
Answer
- True
- False
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