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Year 2 Quiz on Linkage Analysis, created by gina_evans0312 on 26/12/2013.
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genetics and genomics
, updated more than 1 year ago
almost 10 years ago
Metaphase is the most important stage for genetic mapping
Recombination cannot be detected in...
Because both alleles are different
Because both alleles are identical
What indicates linkage?
The no of recombinants
The no of homozygotes
The no of heterozygotes
A generation bred from parents AB & ab, has 1 recombinant out of 20- is linkage involved
Recombinant detecting probes can be fooled if double recombination occurs
Which of the following gametes tend to recombine more around the centromere?
Oocytes tend to recombine
Around the telomeres
Around the centromere
More than spermatocytes
Less than spermatocytes
Most recombination occurs at random
What is 1q42.3 referring to?
Short arm of chromosome 1
Long arm of chromosome 1
Locus position (from telomere to centromere)
Locus position (from centromere to telomere)
Meiosis is made informative or uninformative depending on whether you can track the diseased allele
What must be known for effective meosic analysis?
Grandparent -> Grandchild phenotype
Grandchild & all siblings phenotype
Parent & all siblings -> Grandchild phenotype
Is the following informative for linkage analysis?
Yes- the child is a recombinant
No- the child is heterozygous
No- the father is homozygous
How would you classify this?
This is an informative recombinant
What is true of Recombinant/Human Pedigree Analysis?
The lower the recombination frequency, the more likely the hypothysis is to be correct
The higher the recombination frequency, the more likely the hypothysis is to be correct
A mother has a disease, and has the alleles M1 & M2- what are the two hypothesis for pedigree analysis?
M1 is diseased M2 is healthy
M1 is healthy M2 is diseased
M1 & M2 are healthy
M1 & M2 are diseased
Give the two Recombination frequencies for that above image
0.16 & 0.83
1.66 & 8.33
16.66 & 83.33
A higher recombination frequency means alleles are closer together
Define a Marker
Any mendelian character that can be used to follow a disease through a pedigree
A fluorescent dye used to find particular alleles
A mutagen used to create findable mutations
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