323663
Description
Quiz by gina_evans0312, updated more than 1 year ago
|
Created by gina_evans0312
over 10 years ago
|
|
Question 1
Question
Which Gprotein causes the activation Phospholipase CBeta?
Answer
-
Gq
-
Gs
-
Gi
Question 2
Question
How is Phospholipase CBeta activated?
Answer
-
By GTP binding to the alpha subunit of the Gq protein
-
By ATP binding to the alpha subunit of the Gq protein
-
By GMP binding to the alpha subunit of the Gq protein
Question 3
Question
What is broken down by phospholipase CBeta?
Answer
-
Phosphatidynositol 4,5 bisphophate
-
Phosphatidynositol 3,5 bisphophate
-
Phosphatidynositol 2,4 bisphophate
Question 4
Question
Which product of the PCbeta pathway causes the release of calcium from the ER?
Answer
-
IP3
-
Diacylglycerol
Question 5
Question
What role(s) does the released Ca perform?
Answer
-
Activates protein kinase C
-
Activates protein kinase B
-
Activates various Ca dependent protein kinases
Question 6
Question
What residues are phosphorylated by the protein kinases activated by this pathway?
Answer
-
Serine
-
Threonine
-
Tyrosine
Question 7
Question
Which subunit of Protein Kinase C contains the pseudosubstrate domain?
Answer
-
PS
-
C1A
-
C4
Question 8
Question
What is the function of subunut C1A
Answer
-
DAG binding site
-
Calcium binding site
-
Phosphatidyl serine binding site
Question 9
Question
Do Ca 2+ and phosphatidyl serine bind to subunit C2?
Answer
-
Yes
-
No
Question 10
Question
Which subunits are part of the catalytic domain?
Answer
-
C1A
-
C3
-
C4
-
PS
-
C5
Question 11
Question
ATP binds to C2, True or False?
Answer
-
True
-
False
Question 12
Question
When IP3 causes the increase in cytosolic calcium, what happens to protein kinase C?
Answer
-
It moves to the membrane and binds with DAG
-
It remains in the cytoplasm and binds with DAG
Question 13
Question
Once protein kinase C has bound to DAG in the membrane, what does it then bind to to release the pseudosubstrate from its active site?
Answer
-
Phosphatidylserine
-
Phosphatidylglycine
-
Phosphatidylglutamate
Question 14
Question
Which of the following is a tumor promoting agent?
Answer
-
Phorbol ester
-
Orphol ester
-
Phenyl ester
Question 15
Question
How do tumor promoting agents effect Phospholipase CBeta?
Answer
-
They bind without being degraded, so it becomes hyperactive
-
They stop the alpha subunit binding, so it becomes unreactive
-
They cause the multiplication of the number of PCbeta enzymes in the cell, causing hyperactivity
Want to create your own Quizzes for free with GoConqr? Learn more.