Question 1
Question
[blank_start]Chemotherapeutics[blank_end] prepared synthetically in the lab
Question 2
Question
Antibiotics are [blank_start]by-products[blank_end] of [blank_start]metabolic activity[blank_end] of bacteria and fungi
Answer
-
by-products
-
metabolic activity
Question 3
Question
Classification of antibacterial agents
A- According to spectrum:
1- [blank_start]Narrow[blank_end] spectrum
2- [blank_start]Broad[blank_end] spectrum
Question 4
Question
Classification of antibacterial agents
B- According to the antibacterial effect
1- [blank_start]Bacteriostatic[blank_end]
2- [blank_start]Bactericidal[blank_end]
Answer
-
Bacteriostatic
-
Bactericidal
Question 5
Question
Classification of antibacterial agents
C- According to mechanism of action:
1- Inhibition of [blank_start]cell wall synthesis[blank_end]
2- Inhibition of [blank_start]cell membrane function[blank_end]
3- Inhibition of [blank_start]protein synthesis[blank_end]
4- Inhibition of [blank_start]nucleic acid synthesis[blank_end]
5- Inhibition of [blank_start]bacterial metabolism[blank_end]
Answer
-
cell wall synthesis
-
cell membrane function
-
protein synthesis
-
nucleic acid synthesis
-
bacterial metabolism
Question 6
Question
Target receptor for Inhibition of cell wall synthesis
Question 7
Question
2 groups for Inhibition of cell wall synthesis
1. [blank_start]B lactam[blank_end] drugs
2. [blank_start]Vancomycin[blank_end] & [blank_start]bacitracin[blank_end]
Answer
-
B lactam
-
Vancomycin
-
bacitracin
Question 8
Answer
-
Penicillin
-
cephalosporin
-
polymyxin
-
polyene
Question 9
Question
Penicillins & cephalosporins inhibit early precursors in transpeptidation
Question 10
Question
[blank_start]Vancomycin[blank_end] & [blank_start]bacitracin[blank_end] inhibit early precursors in transpeptidation
Question 11
Question
advantage of β Lactam drugs
Question 12
Question
bacitracin act only on growing cells
Question 13
Question
Inhibition of cell membrane function drugs
Answer
-
polymyxins
-
polyenes
-
Amikacin
-
Tetracyclines
Question 14
Question
Advantages of polymyxins & polyenes
1. [blank_start]Bactericidal[blank_end]
2. [blank_start]can act on non growing cells[blank_end]
Disadvantage of polymyxins & polyenes
1. [blank_start]Toxic effects on kidney & CNS[blank_end]
Answer
-
Bactericidal
-
Selective toxicity
-
can act on non growing cells
-
bacteriostatic
-
Toxic effects on kidney & CNS
-
Act only on growing cells
Question 15
Question
Drugs acting on the 30S ribosomal subunit
Answer
-
Amikacin
-
Gentamicin
-
Tetracyclines
-
Lincomycin
-
Erythromycin
-
oleandomycin
Question 16
Question
Aminoglycosides
1.[blank_start]Amikacin[blank_end]
2. [blank_start]Gentamicin[blank_end]
Question 17
Question
Tetracyclines effective in treatment of Chlamydophila
Question 18
Question
oleandomycin is effective in treatment of intracellular bacteria
Question 19
Question
Tetracyclines: Effective in treatment of intracellular bacteria e.g. [blank_start]Chlamydophila[blank_end] & [blank_start]Brucella[blank_end]
Question 20
Question
Aminoglycosides are [blank_start]Bactericidal[blank_end]
Answer
-
Bactericidal
-
Bacteriostatic
Question 21
Question
Tetracyclines are [blank_start]Bacteriostatic[blank_end]
Answer
-
Bacteriostatic
-
Bactericidal
Question 22
Question
Drugs acting on the 50S ribosomal subunit except
Answer
-
Chloramphenicol
-
Lincomycin
-
Macrolides
-
polymyxins
Question 23
Question
Drugs acting on the 50S ribosomal subunit are [blank_start]Bacteriostatic[blank_end]
Answer
-
Bacteriostatic
-
Bactericidal
Question 24
Question
Macrolides
1. [blank_start]Erythromycin[blank_end]
2. [blank_start]oleandomycin[blank_end]
Answer
-
Erythromycin
-
oleandomycin
Question 25
Question
Inhibition of nucleic acid synthesis
1. [blank_start]Rifampin[blank_end]
2. [blank_start]Quinolones[blank_end]
Question 26
Question
Rifampin: inhibit [blank_start]DNA dependent RNA polymerase[blank_end]
Question 27
Question
Quinolones: inhibit [blank_start]DNA gyrase[blank_end]
Question 28
Question
[blank_start]Rifampin[blank_end]: inhibit DNA dependent RNA polymerase
Answer
-
Rifampin
-
Quinolones
-
oleandomycin
Question 29
Question
Inhibition of bacterial metabolism
1. [blank_start]Sulphonamides[blank_end]
2. [blank_start]Trimethoprim[blank_end]
Answer
-
Sulphonamides
-
Trimethoprim
Question 30
Question
Sulphonamides: inhibit [blank_start]DHFA synthetase[blank_end]
Question 31
Question
Trimethoprim: inhibits [blank_start]DHFA reductase[blank_end]
Question 32
Question
Trimethoprim: inhibits DHFA synthetase
Question 33
Question
Bacterial Resistance to chemotherapeutic agents
1. [blank_start]Non genetic origin[blank_end]
(natural/inherent)
2. [blank_start]Genetic origin[blank_end]
(acquired)
Answer
-
Non genetic origin
-
Genetic origin
Question 34
Question
Genetic origin ([blank_start]acquired[blank_end]) is [blank_start]Unpredictable[blank_end]
Answer
-
acquired
-
inherent
-
Unpredictable
-
predictable
Question 35
Question
Genetic origin
([blank_start]acquired[blank_end])
[blank_start]Unpredictable[blank_end]
1- [blank_start]Chromosomal[blank_end]
([blank_start]Mutation[blank_end]=change in [blank_start]receptor[blank_end])
2- [blank_start]Extrachromosomal[blank_end]
([blank_start]R factor[blank_end] carrying destroying enzymes
Answer
-
acquired
-
Unpredictable
-
receptor
-
Chromosomal
-
R factor
-
Mutation
-
Extrachromosomal
Question 36
Question
Non genetic origin
([blank_start]natural[blank_end]/inherent)
[blank_start]Innate[blank_end], [blank_start]predictable[blank_end]
1- Absence of cell wall ([blank_start]Mycoplasma[blank_end])
2- Permeability barrier in cell envelope ([blank_start]Pseudomonas[blank_end])
3- Non multiplying ([blank_start]TB[blank_end])
Answer
-
natural
-
Innate
-
predictable
-
Mycoplasma
-
Pseudomonas
-
TB
Question 37
Question
Mechanisms of Resistance
1. [blank_start]Drug Inactivation[blank_end]
2. [blank_start]Change of Permeability[blank_end]
3. [blank_start]Alter Target Structure[blank_end] e.g.[blank_start]PBP[blank_end]s, [blank_start]30S[blank_end], [blank_start]50S[blank_end]
4. [blank_start]Alter Metabolic Pathway[blank_end] ([blank_start]utilize preformed FA[blank_end])
Answer
-
Drug Inactivation
-
Change of Permeability
-
Alter Target Structure
-
PBP
-
30S
-
50S
-
Alter Metabolic Pathway
-
utilize preformed FA
Question 38
Question
[blank_start]Cross Resistance[blank_end]
Bacteria resistant to a drug may be resistant to a [blank_start]chemically related[blank_end] one.
Answer
-
Cross Resistance
-
chemically related
Question 39
Question
Antibacterial Drug Combinations
1- [blank_start]Indifference[blank_end] ( 1 + 1= 1 )
2- [blank_start]Addition[blank_end] (1 + 1 = 2 )
3- [blank_start]Synergism[blank_end] ( 1 + 1= 3 )
4- [blank_start]Antagonism[blank_end] ( 1 + 1= 0 )
Answer
-
Indifference
-
Addition
-
Synergism
-
Antagonism
-
reciprocal
-
commensal
Question 40
Question
Synergism
[blank_start]Penicillin[blank_end] + [blank_start]aminoglycoside[blank_end]
[blank_start]Carbenicillin[blank_end] + aminoglycoside
[blank_start]Ampicillin[blank_end] + [blank_start]Metronidazole[blank_end]
Answer
-
Penicillin
-
Erythromycin
-
aminoglycoside
-
Rifampin
-
Carbenicillin
-
Chloramphenicol
-
Ampicillin
-
Tetracycline
-
Metronidazole
-
Macrolides
Question 41
Question
Control of Drug Resistance
1- Give only when [blank_start]indicated[blank_end]
2- Proper choice (according to [blank_start]susceptibility[blank_end])
3- Give in the proper [blank_start]dose[blank_end] for proper [blank_start]time[blank_end]
(To prevent [blank_start]selection pressure[blank_end])
4- Use drug [blank_start]combinations[blank_end]
(simultaneous use of 2 drugs)
5- Avoid [blank_start]abuse[blank_end] of [blank_start]valuable[blank_end] drugs
Answer
-
indicated
-
susceptibility
-
dose
-
time
-
selection pressure
-
combinations
-
abuse
-
valuable