Anemia: ↓ or Ineffective RBC production

Hematopoetic Stem Cell Failure/BM failure
1. Acquired/Hereditary Aplastic Anemia
  1. N RDW, ↑ MCV
2. Fanconi's Anemia
3. Diamond-Blackfan Anemia
Functional Impairment of Erythroid Progenitors
1. Abn DNA sythesis: megaloblastic anemia
  1. ↑ RDW, ↑MCV
    1. Asynchronous RBC maturation
      1. ↓ Folate, B12, IF
        lack of functional IF = pernicious anemia
      2. MDS & erythroleukemia
2. ↑ RDW, ↓ MCV, ↓ HGB, ↓ retic
  1. IDA
    1. defective heme synthesis
      1. most common anemia
  2. Thalassemia
    1. Quantitative ↓ Hgb abn
      1. alpha and beta chain gene deletions
  3. Anemia of Chronic Dx & Inflammation
    1. Fe present but not available
      1. Most common hospital anemia
  4. Sideroblastic Anemia
    1. Acquired, Inherited
      1. Non heme iron trapped in mitochondria
        iron can't be used to make heme
3. Abn Hgb synthesis
N or ↓ retic
Chronic Renal Dx
1. ↓ EPO
  1. BM can't ↑ RBCs to compensate for tissue hypoxia
2. N MCV
3. Uremia, burr cells

Resource summary

	Created by Sarah Phillips about 7 years ago