Th1L07 Clinical use of enzyme measurements


Medicine Y1 (Theme 1 | Cells and organelles) Mind Map on Th1L07 Clinical use of enzyme measurements, created by Emma Allde on 17/08/2016.
Emma Allde
Mind Map by Emma Allde, updated more than 1 year ago
Emma Allde
Created by Emma Allde over 7 years ago

Resource summary

Th1L07 Clinical use of enzyme measurements
  1. Appearance of creatine kinase and lactate dehydrogenase in plasma after myocardial infarction
    1. Increase in CK2 activity 24 hours after
      1. Increase in LDH activity 48 hours after
        1. Isozymes of lactate dehydrogenase can be separated by chromatography
          1. five different isozymes of lactate hydrogenase exist
            1. H4, H3M, H2M2, HM3 and M4
            2. During a myocardial infarction
              1. Endothelial cells rupture, releasing their contents into the blood stream
                1. This increases the serum levels for lactate hydrogenase isozyme 1 and 2 and cane be used as a diagnostic tool
            3. composed of four monomers
              1. heart or muscle type
          2. Clinical uses of enzyme inhibitors
            1. Control of angiotensin production
              1. cleavage of Angiotensin I to Angiotensin II results in peripheral vasoconstriction and aldosterone secretion
                1. Treatment of heart failure with ACE inhibitors prevents sodium/water retention > oedema
            2. Enzyme inhibitors as toxins
              1. Mustard gas, sarin (nerve gases)
                1. Organophosphorus
                  1. Inhibits cholinesterase irreversibly; poisons the enzyme
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