WOUND HEALING

WOUND HEALING

WOUND: disruption of normal structure and function
1. HEALING: results in restoration and function
CONDITIONS REQUIRED FOR HEALING
1. Good nutritional status
  1. Good general health, free from systemic disease
    1. Good blood supply to provide, nutrition, oxygen and waste removal
      1. Freedom from contamination of toxins and foreign bodies
        Infection, immunosuppression, cancer, reduced blood supply impair healing
HEALING BY PRIMARY INTENTION
1. Simple, rapid process in a clean skin wound
  1. Damaged edges are in close proximity
    1. Damage is minimal
3 STAGES IN REPAIR PROCESS:
1. INFLAMMATION: haemostasis, platelets aggregate and form fibrin clot
  1. Inflammatory phase, bacteria phagocytosed, clot infiltrated by PMN's
    1. Cytokines released, cause migration and division of cells
2. PROLIFERATION: fibroblasts enter site
  1. Angiogenisis: new blood vessels form when endothelial cells migrate
    1. Collagen deposition and granulation tissue formation:
      1. Fibroblasts lay down collagen matrix
        Granulation tissue consist of new blood vessels+inflam cells
        Epithelialisation:, e cells migrate to wound edges
        Contraction: Myofibroblasts make wound smaller by contracting
3. MATURATION AND REMODELLING
  1. Granulation tissue replaced by fibrous scar
    1. arranging of collagen fibres for strenght
      1. vascularity reduces, cells removed by apoptosis

Resource summary

	Created by aahughes about 11 years ago