Healing and Repair

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• Regeneration: Destroyed tissue replaced by original tissue, function retained. Repair: half regeneration, half scar tissue Fibrosis: Replacement of tissue with scar tissue.

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• Proliferative Potential: Depends on tissue Volume: How many tissue removed Persistence: Yeah, depends on pathology too Location: Where it got hurt.

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• Triggers by same stimuli that induces inflammation and cellular death. Recruited inflammatory cells.

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• Haemostassis and acute inflammatory response Parenchymal Regeneration Migration and proliferation of fibroblasts Synthesis of extracellular matrix Remodelling of parenchyma (to restore function REstore strength

1. Granulation Tissue

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   • Tissue that proliferate repair Consists of cells like microphages *provide growth factors Fibroblasts Blood vessels Tissue may cause it to look edemic and swollen.
   1. Scar Tissue

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      • More of fibroblast, the result of granulation tissue healing.

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• Clean cut. Neutrophils migrate towards scab. The epidermis is healed within 3 to 4 days. Deep tissues heal within 3 to 4 weeks.

1. Healing in 2nd Intention

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   • Significant loss of epidermal area. Eventually will leave a dip/depression on site. Extensive granulation tissue will form. Normally have wound contraction.

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• Consists of Macrophages *redundancy to create fibroblast proliferation IL-10 Secretion to generate inflammatory cells and parachymal cells (endothelial cells) Signalling to secrete stuff into blood vessels.