Appendicitis

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• Lifetime Risk: 1 in 15 people. Prominent risk age is 10-30 Male predominance. More common in industrialised societies

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• How does it occur... It occur by a few factors, such as the blockage of lumen, over stimulation of the thyriod follicular glands (hyperplasia), or kinking of the appendix.

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• Blockage Then, bacterial proliferation. Then, bacterial invasion into cellular wall. Inflammation measures takes place in the serosa, lymphatics activated, cause acute inflammation. Swelling and increased pressure on the tissue. Worsen situation

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• Outward nothing much. But in histological section it shows much more. Stay tuned. With presecene of faecalith. Disruption of the lumen epithelium Pus Inflammation In a macroscopic view, it turns the granular dull, red surface, vasodilation, congestion and oedema.

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• Pain (colicky) Anorexia, constipation, Nausea or vomiting Fever (low grade) Neutrophil leucocytosis. if it forms to the acute fibrinosuppurative appendicitis state, it will spread thru the serosa. ANd it shifts from centre to right iliac fossa. Localized tenderness and guarding

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• It may burst and spread bacterial pay load into other areas, such as the peritonitis or the subphrenic space (lungs). It may also spread thru the liver portal veins and subsequently destroy the liver.