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Platelet and coagulation disorders

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Mind Map on Platelet and coagulation disorders, created by Pooja Acharya on 09/03/2020.
Pooja Acharya
Mind Map by Pooja Acharya, updated more than 1 year ago
Pooja Acharya
Created by Pooja Acharya over 4 years ago
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Resource summary

Platelet and coagulation disorders
  1. Hemostasis
    1. Sequence of events
      1. Fibrinolysis
        1. TPA
          1. Plasmin
            1. Fibrin
              1. FDP
                1. D-dimer
                  1. Marker of PE
          2. Vasoconstriction
            1. Neurohumoral
              1. Endothelin
              2. Primary plug
                1. Platelet adhesion
                  1. VWF binds to GIb on platelets
                    1. VWF glues subendothelial collagen
                      1. Platelet shape change
                      2. Platelet activation
                        1. Release of platelet contents
                          1. Flip in the phospolipid membrane
                            1. ADP activates the GIIb receptor
                            2. Platelet aggregation
                              1. Binding GIIb betn platelets with fibrinogen
                            3. Secondary hemostatic plug
                              1. Coagulation cascade on platelet membrane
                                1. Instrinsic pathway
                                  1. Surface activation FXII
                                    1. PTT
                                      1. 50: 5O Correction
                                        1. FVII, IX, XI, XII
                                        2. 50:50 correction
                                          1. Circulating antibodies
                                            1. SLE, APLA
                                      2. Extrinsic pathway
                                        1. PT
                                          1. 50:50 correction
                                            1. FVII
                                            2. 50:50 no correction
                                              1. Antibodies
                                          2. Common pathway
                                            1. X-->Xa
                                              1. Proth--> Thrombin
                                                1. Fibrinogen--> Fibrin
                                          3. Clot stabilization
                                            1. FXIII
                                      3. Thrombophilia
                                        1. Virchows triad
                                          1. Hypercoagulability
                                            1. Factor V L mutation
                                              1. Va is resistant for inactivation by APC
                                              2. AT-III Def
                                                1. Thrombin uninhibited
                                                2. PT gene mutation
                                                  1. Increased Prothrombin
                                                  2. HIT
                                                    1. Unfractioned heparin
                                                      1. Thrombocytopenia
                                                        1. Antibodies to PF-2
                                                        2. APLA
                                                          1. Antibodies to Glycoprotein I
                                                            1. False + VDRL
                                                              1. Rec PE
                                                                1. Repeated abortions
                                                                  1. Libmann sack endocarditis
                                                                2. Stasis
                                                                  1. Prolonged immobilization
                                                                  2. Endothelial dysfunction
                                                                    1. Smoking
                                                                      1. Atherosclerosis
                                                                  3. Thrombocytopenia
                                                                    1. Decreased production
                                                                      1. Marrow failure
                                                                        1. Leukemia or infiltration
                                                                        2. Decreased survival
                                                                          1. Acute ITP
                                                                            1. Child after viral
                                                                              1. <20000 results in ICH
                                                                            2. Chronic ITP
                                                                              1. Antibodies to GPIb or GPIIb
                                                                                1. Seen in females,
                                                                                  1. Diagnosis by exclusion
                                                                              2. Quantitative disorder
                                                                                1. Qualitative disorders
                                                                                  1. Bernard soulier
                                                                                    1. Adhesion defect absent GPib
                                                                                      1. RIPA reduced
                                                                                        1. Platelet count normal
                                                                                        2. Glanzmann
                                                                                          1. Platelet aggregation defect
                                                                                            1. Defective GPIIb/IIIa
                                                                                              1. Ristocetin -normal
                                                                                            2. VWD
                                                                                              1. VWF secreted from Endothelial cell
                                                                                                1. Adhesion defect
                                                                                                  1. RIPA reduced
                                                                                                    1. Desmopression increases release of VWF
                                                                                                    2. MAHA
                                                                                                      1. TTP
                                                                                                        1. Neurological
                                                                                                          1. Thrombocytopenia
                                                                                                            1. Renal failure
                                                                                                              1. Fever
                                                                                                                1. Hemolytic anemia
                                                                                                                  1. Defect in ADMATS-13
                                                                                                                  2. HUS
                                                                                                                    1. Endothelial dysfunction due to toxin
                                                                                                                      1. After eating hamburger
                                                                                                                        1. Renal failure
                                                                                                                          1. No neurological manifestation
                                                                                                                            1. ECOLI O157:H7
                                                                                                                            2. DIC
                                                                                                                              1. Bleeding from iv canula
                                                                                                                                1. Extensive endothelial injury
                                                                                                                                  1. TF release
                                                                                                                                  2. etiology
                                                                                                                                    1. Obstretic complications
                                                                                                                                      1. Sepsis
                                                                                                                                        1. severe burns
                                                                                                                                        2. Lab diagnosis
                                                                                                                                          1. Increased PT, PTT INR
                                                                                                                                            1. Low platelets
                                                                                                                                              1. Reduced fibrinogen
                                                                                                                                          2. Coagulation factor defects
                                                                                                                                            1. Hemophilia A
                                                                                                                                              1. Raised PTT
                                                                                                                                                1. 50:50 Mix correction
                                                                                                                                                  1. FVIII DEF
                                                                                                                                                    1. X- Recessive
                                                                                                                                                    2. Hmeophilia B
                                                                                                                                                      1. FIX Deficiency
                                                                                                                                                        1. XR
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