17335204
Description
Mind Map by Alya Almualla, updated more than 1 year ago
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Created by Alya Almualla
about 5 years ago
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Salma with facial rash
- Due to
- Systemic Lupus Erythematosus
- Epidemiology
- Prevalence and incidence
- More in black than white
- More in women than men
- More in Hispanics
- More in Indians/Alaska Natives
- More in black than white
- US
- Prevalence is 20-150/100,000 people
- White women "Prevalence is 164/100,000 people"
- African American women "Prevalence is 406/100,000 people"
- Prevalence is 20-150/100,000 people
- In Europe & North America "Prevalence is 24/100,000 people"
- In North America, South America, Europe, & Asia "Incidence is 1-25/100,000 people"
- UAE "2012"
- Incidence was 2.1/100,000 people
- Prevalence was 103/100,000 people
- Incidence was 2.1/100,000 people
- Death rates
- Prevalence and incidence
- Connective Tissue Disorder
- Rheumatoid arthritis
- Symmetric joint involvement
- Joints of the hands, feet, wrists, elbows, knees and ankles
- Joints of the hands, feet, wrists, elbows, knees and ankles
- Morning stiffness lasting > 1 hour
- Women (30 - 60 years)
- Symmetric joint involvement
- Sjögren's syndrome
- Destruction of the salivary and lacrimal glands
- Women (40 to 60 years)
- Type 4 hypersensitivity
- Destruction of the salivary and lacrimal glands
- Scleroderma \ Systemic sclerosis
- Fibroblast activation and
excess collagen deposition
- Fibroblast activation and
excess collagen deposition
- Polymyositis
- Progressive symmetric proximal muscle weakness
- Progressive symmetric proximal muscle weakness
- Dermatomyositis
- Gottron’s sign
- Symmetric erythematous eruption over knuckles
- Symmetric erythematous eruption over knuckles
- Heliotrope rash
- Reddish eruption on upper eyelids
- Reddish eruption on upper eyelids
- Shawl sign
- Erythematous rash over neck, upper chest and shoulders
- Erythematous rash over neck, upper chest and shoulders
- Gottron’s sign
- Mixed connective tissue disease
- Autoimmune mediated tissue
damage with mixed features of
SLE, scleroderma, polymyositis
- Autoimmune mediated tissue
damage with mixed features of
SLE, scleroderma, polymyositis
- Psoriatic arthritis
- Joint inflammation in
patients with psoriasis
- HLA-B27 & environmental factors
- Joint inflammation in
patients with psoriasis
- Rheumatoid arthritis
- Risk factors
- Gender "Women"
- Age "15 - 44"
- Race or ethnicity
- Family history "5% - 13% chance"
- Genetic factors
- Gender "Women"
- Pathogenesis
- Failure to maintain self-tolerance
- Tissue injury due to immune complex deposition
- Autoantibodies "Type II hypersensitivity"
- Immunofluorescence "IgG"
- Deposits of immunoglobulin
- Granular pattern "Kidney"
- Deposits of immunoglobulin
- Failure to maintain self-tolerance
- Differential Diagnosis
- Adult-onset Still disease
- Behcet syndrome
- Chronic fatigue syndrome
- Endocarditis
- Fibromyalgia
- HIV infection
- Inflammatory bowel disease
- Lyme disease
- Reactive arthritis
- Sarcoidosis
- Thyroid disease
- Adult-onset Still disease
- Clinical manifestation
- Tachypnea
- Cough
- Photosensitivity
- Pleuritis/ Pleural effusion
- Weight loss
- Fatigue
- Fever & Increase infection
- Arthritis
- Emotional lability
- Hematological disorder
- Neurologic disorder
- Raynaud’s phenomenon
- Pericarditis
- Vasculitis
- Rash
- Erythematous
- Butterfly
- Erythematous
- Lupus nephritis
- Proteinuria
- Hematuria
- Proteinuria
- Tachypnea
- Types
- Drug induced
- Anti-histone antibodies
- No involvement of kidney or brain
- Sulfasalazine, Hydralazine, Isoniazid, Procainamide / Phenytoin, Statins
- Symptoms: Arthralgia - myalgia - Fatigue - Serositis
- Anti-histone antibodies
- Neonatal lupus
- In fetus with mothers that have
- Anti Ro\SSA - anti La\SSB - anti U1RNP
- Anti Ro\SSA - anti La\SSB - anti U1RNP
- Placental transmission of maternal IgG abs
- Rash resembling Subcutaneous cutaneous lupus erythematosus
- In fetus with mothers that have
- Cutaneous lupus
- Acute
- Butterfly rash
- Butterfly rash
- Subacute
- Annular or psoriasiform plaques
- Annular or psoriasiform plaques
- Chronic
- Related to photosensitivity
- Acute
- Chronic Discoid Lupus Erythematosus
- Red inflamed, coin-shaped patches of skin with
a scaling and crusty appearance
- ANA
- Red inflamed, coin-shaped patches of skin with
a scaling and crusty appearance
- Drug induced
- Investigations
- CBC & differential
- Activated PTT
- BUN & electrolytes
- ESR & CRP
- Antinuclear antibodies, (ds) DNA, smith antigen
- Urinalysis
- Chest x-ray
- ECG
- C3, C4, CH50
- Anti-ro & anti-La abs
- Thyroglobulin abs & Thyroid peroxidase abs
- IgG
- CBC & differential
- Management
- Immunosuppressants
- General Mechanisms of Action
- Mono- and polyclonal antibodies
that block T-cell surface molecules
- Antilymphocyte and antithymocyte Globulins
- Basiliximab
- Daclizumab
- Belimumab (B-cells)
- Rituximab (B-cells)
- Antilymphocyte and antithymocyte Globulins
- Interference with cytokine
production or action
- Disruption of cell metabolism,
preventing lymphocyte proliferation
- Mono- and polyclonal antibodies
that block T-cell surface molecules
- Corticosteroids
- Mechanisms of action
- Mechanisms of action
- Hydroxychloroquine
- Decreases T-cell activation
- Decreases T-cell activation
- Antibodies
- General Mechanisms of Action
- Immunosuppressants
- Complications
- Blood clots / Vasculitis
- Pericarditis / Heart attack
- Stroke / Memory changes / Behavioral changes / Seizures
- Pleuritis
- Kidney inflammation / Decreased kidney function / Kidney failure
- Pregnancy complications & miscarriage
- Blood clots / Vasculitis
- Prognosis
- Clinically unpredictable
- 5-year survival rate (90%)
- 10-year survival rate (80%)
- Clinically unpredictable
- Epidemiology
- Systemic Lupus Erythematosus
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