Salma With Facial Rash

Immunology Overview
1. Tolerance
2. MHC Review
Classification of autoimmune diseases
1. Organ specific Autoimmune Diseases
2. Systemic autoimmune Diseases
Connective tissue disorders
Systemic Lupus Erythematosus
1. Differential Diagnosis
  1. Rheummatoid Arthritis
  2. Mixed connective tissue disease
  3. Systemic sclerosis
  4. Sjögren's syndrome
  5. Vasculitis
2. Causes & Risk factors
  1. Gender - Females
  2. Age - 15-44
  3. Ethnicity- African Americans
  4. Family History
  5. Environmental Triggers
    1. Viral Infection
    2. UV waves
    3. Smoke
    4. Sun Exposure
3. Types
  1. Drug Induced Lupus
    1. Ends with cessation of drugs
    2. Anti-Histone AB
    3. Drugs: Hydralazine Isoniazid Minocycline Procainamide Quinidine
  2. Primary SLE
  3. Neonatal Lupus
    1. Cutaneous lupus lesions
    2. congenital heart block
4. Pathophysiology
  1. 1) Apoptosis
  2. 2) Nucleic Acids
  3. 3) Innate Immunity
  4. 4) Adaptive Immunity
5. Investigations
  2. Auto antibodies in SLE
    1. 1) DsDNA 2)RO and La 3)SM 4)Cardiolipin 5)Histones 6)Sm 7)RNB
6. Diagnosis
7. Management
  1. Systemic therapies
    1. Hydroxychloroquine is the DOC
  2. Cutaneous manifestations
    1. Sun Screen
    2. Topical Glucocrticoids
  3. Musculoskeletal Manifestations
    1. NSAIDs
8. Complications

Resource summary

	Created by Safaa Fayiz over 5 years ago