Tremor is defined as a rhythmic,
involuntary, oscillating movement of
a body part occurring in isolation or
as part of a clinical syndrome
Dopamine loss in
During this initial stage, the person has mild symptoms that
generally do not interfere with daily activities. Tremor and
other movement symptoms occur on one side of the body only.
Changes in posture, walking and facial expressions occur.
Symptoms start getting worse. Tremor,
rigidity and other movement symptoms
affect both sides of the body. Walking
problems and poor posture may be apparent.
The person is still able to live alone, but daily
tasks are more difficult and lengthy.
Considered mid-stage, loss of balance and slowness of
movements are hallmarks. Falls are more common. The
person is still fully independent, but symptoms
significantly impair activities such as dressing and eating.
At this point, symptoms are severe and
limiting. It’s possible to stand without
assistance, but movement may require a
walker. The person needs help with activities
of daily living and is unable to live alone.
PALLOR of the
α-synuclein, a protein involved
in synaptic transmission.