RNA Viruses

Description

Virology Mind Map on RNA Viruses, created by ravi shah on 16/06/2013.
ravi shah
Mind Map by ravi shah, updated more than 1 year ago
ravi shah
Created by ravi shah over 10 years ago
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Resource summary

RNA Viruses
  1. Positive Sense ss

    Annotations:

    • quick note - arboviruses use ticks, mosquitoes, and flies to infect - include toga, flavi, and bunyaviridae 
    1. Picornavirus
      1. Enterovirus

        Annotations:

        • mcc of aseptic meningitis especially in kids remember fungal meningitis mcc is cryptococcal
        1. Rhinovirus

          Annotations:

          • most common cause of hospitalizations in children. second mcc of bronchiolitis vaccine not feasible common cold.
          1. Coxsackie

            Annotations:

            • cav - herpangina (EV7) - always on posterior end of mouth (herpes leaves lesions on anterior mouth); exanthem and enanthem stuff CA16 - hand foot mouth (ev71) cbv - myocarditis and pericarditis
            1. Poliovirus

              Annotations:

              • 1 2 3  2 is pretty much gone. ev71 also cause polio. fecal oral. vaccines - opv ipv (we use ipv-inactivated) opv can cause disease (live)
              1. Echovirus
              2. Hepatovirus

                Annotations:

                • hep a vaccine preventable.  not that bad.
                1. Parechovirus
                  1. Kobuvirus

                    Annotations:

                    • aiichi - diarrhea
                  2. Coronavirus

                    Annotations:

                    • sars mucosally restricted new outbreak in saudi arabia 5/2013 mainly causes respiratory ilness; can cause GI issues in infants. no vaccine.
                    1. Flaviviridae

                      Annotations:

                      • ixodes ticks - encephalitis these all cause encephalitis and hemorrhagic or normal fever.
                      1. Japanese Encephalitis Virus Group

                        Annotations:

                        • JEV - vaccine preventable St. louis encephalitis West nile virus
                        1. Yellow Fever Virus

                          Annotations:

                          • vaccine preventable. can be pretty darn serious. black vomitus
                          1. Dengue Fever

                            Annotations:

                            • 4 serotypes. lifelong immunity if you get it. SOME cross reactivity.  no vaccine. 4 types of fever and rash: undifferentiated, classical hemorrhagic dengue shock
                            1. Hepacivirus - Hep c
                            2. Astrovirus

                              Annotations:

                              • diarrhea. adenovirus 41 40 also cause diarrhea
                              1. Calicivirus

                                Annotations:

                                • smaller than rotavirus in size.
                                1. Norovirus

                                  Annotations:

                                  • fluids and electrolytes. less severe than rota in children watery diarrhea.just wash your hands.cruise ship virus
                                2. Togaviridae
                                  1. Alphaviridae

                                    Annotations:

                                    • old world - chikungunya new world - WEEV, EEEV, VEEV no treatment. just supportive. essentially - chikungunya = rash
                                    1. Rubivirus

                                      Annotations:

                                      • rubella - mmr live vaccine. cataracts cardiac problems not an arbovirus - spread person to person congenital - dangerous during 1 tm of pregnancy only.
                                  2. Negative sense ss
                                    1. Orthomyxoviridae

                                      Annotations:

                                      • segmented boar
                                      1. Influenza A B C

                                        Annotations:

                                        • Na inhibitors - oseltamivir, zanamivir (>7 years old; inhaled, works better than oseltamivir) M2 ion channel inh (type A only) -  amantidine, rimantidine; current strains aren't susceptible. all HA's transmitted through water fowl parabasic region - makes virus "high path"
                                      2. Paromyxoviridae
                                        1. Mucosally restricted
                                          1. Parainfluenza

                                            Annotations:

                                            • croup steeple sign. NOT epiglottitis (HITB) odd years have outbreaks use steroids to prevent closing of trachea
                                            1. hMPV
                                              1. RSV

                                                Annotations:

                                                • number one cause of bronchiolitis try ribavirin but really use synagis (mAB) need 10x more antibody for nose infection than lung infection.
                                              2. Systemic
                                                1. Morbillivirus - measles

                                                  Annotations:

                                                  • koplik's spots rash everywhere very infectious - can be lethal mmr - vaccine.
                                                  1. rubulavirus - mumps

                                                    Annotations:

                                                    • parotitis (can be any gland really) isolate individual.  mmr - live vaccine.
                                                2. Rhabdoviridae

                                                  Annotations:

                                                  • Rabies - vaccine 3 times before exposure. causes unstoppable encephalitis. bullet shaped virus. negri bodies. in texas - skunks and bats. 
                                                  1. Filoviridae

                                                    Annotations:

                                                    • fruit bats hemorrhagic fever
                                                    1. Marburgvirus
                                                      1. Ebolavirus
                                                      2. Bunyaviridae

                                                        Annotations:

                                                        • segmented boar
                                                        1. Bunyavirus

                                                          Annotations:

                                                          • California encephalitis lacross
                                                          1. Hantavirus

                                                            Annotations:

                                                            • HFRS - hantaan and seoul use ribavirin HPS - sin nombre virus. deer mouse and cotton rat. variants named by location. progresses quickly.
                                                            1. Phlebovirus

                                                              Annotations:

                                                              • sandfly. rift valley fever
                                                              1. Nairovirus

                                                                Annotations:

                                                                • tick borne crimean congo hemorrhagic fever use ribavirin for cchf
                                                              2. Deltavirus

                                                                Annotations:

                                                                • hep d?
                                                              3. Ambisense
                                                                1. Arenaviridae

                                                                  Annotations:

                                                                  • segmented boar
                                                                  1. LCM

                                                                    Annotations:

                                                                    • aseptic meningitis
                                                                    1. Lassa Fever

                                                                      Annotations:

                                                                      • hemorrhagic nausea, vomiting, diarrhea use ribavirin
                                                                  2. double stranded
                                                                    1. Reoviridae

                                                                      Annotations:

                                                                      • segmented boar
                                                                      1. rotavirus

                                                                        Annotations:

                                                                        • watery diarrhea. 2 live vaccines; intussusception risk number 1 cause of diarrhea in developing countries. destroy the villi after 12 hours as seen on biopsy.
                                                                        1. coltivirus

                                                                          Annotations:

                                                                          • colorado tick fever
                                                                          1. reovirus
                                                                            1. orbivirus
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