EBV Infection


Virology (Epstein Barr Virus) Flashcards on EBV Infection, created by gina_evans0312 on 10/02/2014.
Flashcards by gina_evans0312, updated more than 1 year ago
Created by gina_evans0312 about 10 years ago

Resource summary

Question Answer
Age of host Determines the effect of primary infection
EBV Carriers at Risk of Cancer Immunocompromised & genetically unlucky
Virus Integration Doesn't happen- remains an extrachromosomal episome
Genome Size & Type Large DNA virus
Genome Stability High- rarely mutates
Latency Enters this phase in some hosts- the form that causes cancers
Avoiding Immune Surveillance- Avoid Cytotoxic T-Cell Blocking antigen processing/presenting by phagocytes
Avoiding Immune Surveillance- Latency Suppression of viral gene expression that makes immune detection impossible
Avoiding Immune Surveillance- Response Modification EBV can modify the immune response to its detection, causing the release of inflammatory cytokines
Source of Infection Usually through saliva
Site of Infection Most commonly B cells
CD21 Together with CD19, it forms the B cell receptor- EBV binds to it to enter the cell
GP350 Used by EBV to bind to CD21, which allows it to enter the cell by endocytosis
Viral Replication Cycle Lytic
Characteristic Of Lytic Replication IgG's against viral capsid proteins
Exit From Cell Endocytosis, so cell isn't killed
Viral DNA Polymerase Responsible for copying the genome in the lytic cycle
Products of Latency Stage Doesn't result in EB virons, allowing it to avoid the immune system
Length of Infection Before Latency is Activated 3 to 6 weeks
Host DNA Polymerase Responsible for copying the genome in the latent phase
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