Renal Regulation of ECF Volume

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The Kidneys Mind Map on Renal Regulation of ECF Volume, created by jessica.neilan on 22/05/2013.
jessica.neilan
Mind Map by jessica.neilan, updated more than 1 year ago
jessica.neilan
Created by jessica.neilan about 11 years ago
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Resource summary

Renal Regulation of ECF Volume
  1. Natriuresius: with positive Na balance there is an increase in ECF volume which causes an increase in Na excretion
    1. Effective Circulating Volume: the portion of the ECF that is contained within the vascular system and is effectively perfusing tissue
      1. Varies directly with ECF volume, blood pressure and cardiac output
      2. Volume Sensing Systems
        1. CARDIOVASCULAR
          1. Baroreceptors
            1. Stretch receptors
              1. Pressure receptors
                1. 5% change in pressure is required to evoke a response
                2. Alters (decreases) sympthetic activity and ADH secretion
                  1. afferent arteriole constricted by alpha adrenergic receptor
                    1. Decreases hydrostatic pressure within glomerular capillary lumen
                      1. Decrease in GFR
                        1. Filtered Na is reduced
                          1. Renin secreted
                            1. increased SNS activity drceases excretion of Na to restore ECF
                  2. JUXTAGLOMERULAR APPARATUS: decrease in pressure causes secretion of renin
                    1. Atrial myocytes release peptide hormone ATRIAL NATRIURETIC PEPTIDE ANP during volume expansion
                      1. Antagonises renin-AII-aldosterone system
                        1. Afferent dilation to increase GFR so more Na is filtered
                          1. Inhibits renin secretion to reduce aldosterone release
                            1. reduces ADH release
                              1. Inhibits Na reabsorbtion in collecting duct
                          2. Raises cGMP levels
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