103147
Description
Mind Map by jessica.neilan, updated more than 1 year ago
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Created by jessica.neilan
about 11 years ago
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Renal Regulation of ECF Volume
- Natriuresius: with positive Na balance there is an increase in ECF volume which causes an increase in Na excretion
- Effective Circulating Volume: the portion of the ECF that is contained within the vascular system and is effectively perfusing tissue
- Varies directly with ECF volume, blood pressure and cardiac output
- Varies directly with ECF volume, blood pressure and cardiac output
- Volume Sensing Systems
- CARDIOVASCULAR
- Baroreceptors
- Stretch receptors
- Pressure receptors
- 5% change in pressure is required to evoke a response
- Baroreceptors
- Alters (decreases) sympthetic activity and ADH secretion
- afferent arteriole constricted by alpha adrenergic receptor
- Decreases hydrostatic pressure within glomerular capillary lumen
- Decrease in GFR
- Filtered Na is reduced
- Renin secreted
- increased SNS activity drceases excretion of Na to restore ECF
- increased SNS activity drceases excretion of Na to restore ECF
- Renin secreted
- Filtered Na is reduced
- Decrease in GFR
- Decreases hydrostatic pressure within glomerular capillary lumen
- afferent arteriole constricted by alpha adrenergic receptor
- JUXTAGLOMERULAR APPARATUS: decrease in pressure causes secretion of renin
- Atrial myocytes release peptide hormone ATRIAL NATRIURETIC PEPTIDE ANP during volume expansion
- Antagonises renin-AII-aldosterone system
- Afferent dilation to increase GFR so more Na is filtered
- Inhibits renin secretion to reduce aldosterone release
- reduces ADH release
- Inhibits Na reabsorbtion in collecting duct
- Inhibits Na reabsorbtion in collecting duct
- reduces ADH release
- Inhibits renin secretion to reduce aldosterone release
- Raises cGMP levels
- Afferent dilation to increase GFR so more Na is filtered
- Antagonises renin-AII-aldosterone system
- CARDIOVASCULAR
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