91533
Description
Flashcards by Bhavi Mistry, updated more than 1 year ago
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Created by Bhavi Mistry
over 11 years ago
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| Question | Answer |
| B antagonists | Treatment of CV symptoms of hyperthyroidism (decreases BP and HR) |
| Radio iodine (131 I-) | Concentration in thyroid gland (destroys follicle cells) NOT associated with risk of tumours NOT for use in Children/Pregnant women 2-3 weeks to take effect |
| Tetracosactide | ACTH analogue hypoglucocorticoidism |
| Hydrocortisone | Steroid Hypoglucocorticoidism |
| Sermorelin | Growth hormone releasing factor analogue Treatment of too little GH |
| Somatotropin | Replacement therapy for too little GH |
| Octreotride, Lanperotride | Somatostatin inhibitors (somatostatin inhibits GH release from anterior pituitary somatotrophs) |
| Mechanism of action of theyroid hormone | Binds to TR and RXR which have a positive or negative effect on gene transcriptors (e.g. Increased contractility in the heart due to balance of myosin components - Gene expression regulated) |
| Chemical causes of Hypothyroidism | Interferon exposure (from Hep B/C) - risk of autoimmune disorder Lithium (bipolar treatment) Amiloroderon - decreases Iodide intake by 37% |
| Hypothyroidism diagnosis | Low T3 and T4 High TSH Tg Ab presence (autoantibody presence) Hyper cholesterolaemia as thyroid increase LDLR expression) |
| Soloxinr (levothyroxine sodium, T4) | Given orally Standard replacement therapy for hypothyroidism |
| Tetroxin (tri-iodothyronine, liothyronine, T3) | Hypothyroidism replacement therapy |
| NI/KI | For iodide deficiency in hypothyroidism |
| T3 metabolism | Max levels achieved in 1 day More potent |
| T4 metabolism | Slow Max levels achieved at day 10 More prevalent |
| Hyperthyroidism diagnosis | Symptoms Goitre/mass Increased T4 levels Decreased TSH levels |
| Thiureylenes | Thyroperoxidase inhibitor Inhibits T3/4 secretion |
| Thiureylenes | Thyroperoxidase inhibitor Inhibits T3/4 secretion |
| Carbimazole | Thyroperoxidase inhibitor Inhibits T3/4 secretion |
| High Iodide doses | Hyperthyroidism treatment Reduced T3/4 synthesis and release - used acutely |
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