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| Question | Answer |
| SRY | (Sex-determining region Y) is gene on the Y chromosome. This intronless gene encodes a transcription factor that initiates male sex determination. allows bipotential primordial gonad cells to differentiate and proliferate |
| although SRYis the trigger to sexual differentiation, other genes are also involved, these include | 1. FTZ-F1 (SF-1) 2. SOX9 |
| Is Sox9: an SRY-target gene? - EVIDENCE | 1. Sox9 expression is strongly upregulated soon after the expression of SRY begins, whereas it is downregulated in the ovary 2. SRY-positive cells exclusively become SOX9-positive Sertoli cells |
| SRY gene encodes a gene that affects | testicular differentiation. |
| Following Sry activation and testes development | male determining signal is sent out via two factors, anti-Mullerian hormone (from sertoli cells) and testosterone. these cause the major differences between males and females. |
| All other differences between sexes are secondary and due to | ‘turning on’ of genes encoding hormones or factors produced by the gonads. |
| In the absence of a signal (testis determining factor) | ovaries are formed. |
| The primary event of sex determination is the | differentiation of this gonadal tissue into testes rather than ovaries. Differentiation of gonadal tissue causes a male determining signal to be sent out via anti-Mullerian hormone and testosterone |
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