C.difficile (And Pseudomembranous Colitis)

Description

Medical Microbiology (Clostridium Family) Flashcards on C.difficile (And Pseudomembranous Colitis), created by gina_evans0312 on 03/04/2014.
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Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312 over 10 years ago
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Resource summary

Question Answer
Role Common indicator of infection control in hospitals
Source Human Gut
Host Immunity If host is receiving broad spectrum antibiotics
Symptoms Loose, smelly, bloody stools
Disease Caused Pseudomembranous Colitis
Virulence Factors Toxins A, B & Binary
Toxin A- Method of Action Acts on apic side, increases gap between cells so toxin B can enter
Toxin B & A- Effect Recruit neutrophils and kills cells (cytotoxic)
Pseudomembranous Colitis- Effect Exaggerated inflammatory response
Pseudomembranous Colitis- Pathology Pseudomembranes form in gut, made of dead leukocytes and epithelial cells
Pseudomembranous Colitis- Diagnosis Stool sample (though C.difficile is hard to culture, look at cytopathic effect on cells)
Pseudomembranous Colitis- Diagnosis (ELISA/PCR) PCR is more effective, but most labs use ELISA assays
Pseudomembranous Colitis- Treatment Stop broad spectrum Antibiotics, start using C.difficile specific ones (also increase infection control practices)
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