609642
Description
Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
over 10 years ago
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| Question | Answer |
| Host Defenses- Urine | High osmolarity and urea concentration- antibacterial properties |
| Host Defenses-Sphincters | They existed |
| Part of UTI That Isn't Sterile | Distal urether |
| Environment- E.Coli | Endogenous intestinal bacteria |
| E.Coli- Ascending Route of Infection | Endogenous intestine E.Coli colonise the female urethra and ascend into the bladder |
| UPEC | Uropathogenic E.Coli |
| UPEC- Adhesins | Bind to UTI epithelial cell receptors |
| UPEC Adhesins- Type 1 Fibriae | Bind to to mannosideases (abundant in bladder cell epithelium) |
| UPEC Adhesins- P. Fimbriae | Bind to glycolipids (abundant in renal epithelium) |
| UPEC Adhesins- Adherence | Adherence activates TLRs, leading to cytokine production... |
| TLR4 mutations | Associated with ABU |
| EPEC- Immune Response (Chemokine Receptor CXCR1) | Associated with neutraphil movement across the epithelium |
| CXCR1 Deficiency | Associated with severe pyelenephritis |
| EPEC Virulence Factors- Siderophoes | Increase possible metabolites i.e. Aerobactins to acquire iron |
| EPEC Virulence Factors- Toxins | I.e. Haemolytics |
| EPEC Virulence Factors- Capsule | Prevents phagocytosis |
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