630643
Description
Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
over 10 years ago
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| Question | Answer |
| Costimulation- Role | Secondary signal required to prevent overstimulation of T-cells |
| Costimulation- Signal | Binding of CD28 (on T-cells) and B7.1/7.2 on APC |
| Costimulation- Anergy Signal | If antigen is presenting with Co-stimulation occurring, T-cell is permanently deactivated |
| Costimulation- Prevention of Autoimmunity | Non Professional APCs don't have B7, so T-cells cannot be activated by normal, native cells |
| Inhibition of T-cells- CTLA-4 | A CD28 homologue activated by CD28-B7 binding that competes with CD28 for B7 |
| Inhibition of T-cells- CTLA-4 Affinity | 20x higher than B7 |
| Inhibition of T-cells- CTLA-4 Role | Signals T cell to downregulate response |
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