Salmonella and Typhoid

Description

Medical Microbiology (G.I Tract Infections) Flashcards on Salmonella and Typhoid, created by gina_evans0312 on 01/03/2014.
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Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312 over 10 years ago
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Resource summary

Question Answer
Resevoir A human case or carrier
Transmission Through contaminated food (can incubate for 7-14 days)
Symptoms Fever (20% mortalility) and complications- ulcers, meningitis
Adherence to cells Type III Secretory system
Macrophage Invasion Used to enter lymph, where it can enter the blood
Primary Bacteraemia Where s.typhi enter the blood to infect other organs (i.e. the Gall Bladder)
Secondary Bacteremia Where bacteria leave the organs they have colonies to enter the blood again
Cause of Symptoms Secondary Bacteremia
Cause of Carrier Bacteria have colonise the gall bladder but no symptoms are produced
Salmonella Pathogenicity Island Allows s.typhi to avoid Toll Like Receptors
V.I Capsule protein that protects it from TLR4
TV.I Inhibits flagelling expression, that protects from TLR5
S. typhi Resistance in the Gall Bladder Can bind to gall stones, forming a biofilm and preventing antibiotic removal
Intracellular Multiplication Hides in the gall bladder epithelium and multiplies
Treatment Antibiotics (and possible gall bladder removal)
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