Noradrenergic Drugs

Question	Answer
Alpha-Methyl-P-Tyrosine- Method of Action	Competitive inhibitor of tyrosine hydroxylase
Alpha-Methyl-P-Tyrosine- Effect	Inhibits catecholamine synthesis
Alpha-Methyl-P-Tyrosine- Treats	Hypertension
Alpha-Methyl-DOPA- Mode of Action	Outcompetes DOPA for DOPA decarboxylase
Alpha-Methyl-DOPA- Effect	Inhibits catecholamine synthesis, but converted by pathway in to less active form of noradrenaline
Alpha-Methyl-DOPA- Treats	Hypertension
Reserprine- Mode of Action	Blocks storage vesicles, preventing dopamine storage
Reserprine- Effect	NA accumulates in the cytoplasm and is destroyed by Monoamine Oxidase
Reserprine- Treats	Psychosis and hypertension
Reserprine- Major Side Effect	Depression
Guanathidine- Mode of Action	Displaces noradrenaline from the vesicle
Guanathidine- Effect	NA is broken down by Monoamine Oxidase
Guanethidine- Treats	Blood pressure (red. cardiac output & causes vasodilation)

Resource summary

	Created by gina_evans0312 over 10 years ago