2873061
Description
Flashcards by jenny schneider, updated more than 1 year ago
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Created by jenny schneider
about 9 years ago
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| Question | Answer |
| Describe the design of an OROS controlled release tablet (type used in Adalat OROS) | |
| Describe the design of an insoluble matrix tablet (used to produced controlled/extended/sustained release) | drug is dispersed in matrix such as wax or polymer that does not dissolve, fluid permeates in and dissolves drug which leeches out (like a sponge) |
| Cardizem CD capsules are controlled release and are capsules with beads inside. Explain how controlled release is produced | Beads in capsule have a polymer membrane which does not dissolve. Fluid enters through this and dissolve drug which diffuses out |
| Some cardiovascular drugs are sustained/extended release tablets that are hydrophilic matrix design. Explain how extended/sustained release is produced in this design | drug is compressed in mix with hydrophilic polymer which swells/gels in contact with fluid. fluid diffuses across gel and dissolves drug and drug then diffuses out, also some erosion |
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