Ampicillin

Description

Nursing SFE Nursing Flashcards on Ampicillin, created by Em J on 03/06/2018.
Em J
Flashcards by Em J, updated more than 1 year ago
Em J
Created by Em J over 6 years ago
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Resource summary

Question Answer
Trade names Ampicyn - Ibimycin - Austrapen
Chemical name Aminobenzylpenicillin
Therapeutic class anti-infective
Pharmacological class antibiotic- penicillin
Indications Chronic bronchitis CAP (community acquired pneumonia) Gonnococal infection Broad spectrum
Actions Bactericidal; interfere with bacterial cell wall peptidoglycan synthesis by binding to penicillin-binding proteins, eventually leading to cell lysis and death.
Pharmacokinetics (absorption) Not well absorbed in GIT - best given IV for absorption
Distribution Does cross placenta and enter breast milk - however is reportedly safe according to AMH
Metabolism & excretion partially metabolised in the liver, with the remainder of the drug excreted through the kidneys in urine
Contraindications & precautions Penicillin allergy! Those with heart failure or on sodium restriction - high levels of sodium Immunocompromised individuals = high incidence of rash Renal impairment 
Adverse reactions Skin: rash GIT: diarrhoea, N + V, CNS: neurotoxicity at high doses/ renal impairment
Assessment requirements Obtain specimen for culture Baseline vital signs  Monitor person's response to administration
Education Tell patients to report adverse effects and the drink lots of fluids, and keep up nutrition.
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