Physical Modifications

Question

Physical modifications are reversible

Answer 1

Disulphide bond formation

Answer 2

Hydrogen bond formation

Answer 3

Glycosylation

Answer 4

Outside the cell

Answer 5

The cytoplasm

Answer 6

I.e. Oxidative environments

Answer 7

They're heat stable

Answer 8

They're protease resitant

Answer 9

They're structurally resilient

Answer 10

The ribosome

Answer 11

Maristic acid

Answer 12

Maristoylate

Answer 13

Maristoyl-3-phosphate

Answer 14

Saturated & hydrophobic

Answer 15

Unsaturated & hydrophilic

Answer 16

It polarises a protein

Answer 17

It binds a protein to a membrane

Answer 18

It binds two ends of a protein together

Answer 19

The N-terminus

Answer 20

The C-terminus

Answer 21

MGXXX(T/S)

Answer 22

MPXXX(G/F)

Answer 23

SDXXX(S/R)

Answer 24

First the phenylalinine is removed

Answer 25

First the methionine is removed

Answer 26

First the tyrosine is removed

Answer 27

Then the substrate is added to the glycine

Answer 28

Then the substrate is added to the leucine

Answer 29

Then the substrate is added to the isoleucine

Answer 30

Geranylgeranyl

Answer 31

In a CAAX box (where A should be Alanine, but anything small and hydrophobic will do)

Answer 32

In a FAAX box (where A should be Isoleucine, but anything small and hydrophobic will do)

Answer 33

In a CAAT box (where A should be Alanine, but anything small and hydrophobic will do)

Answer 34

C-Mannosylation

Answer 35

Phosphoserine Linked

Answer 36

The Asn in an NX(S/T)

Answer 37

The Phe in an FX(S/T)

Answer 38

The Gly in a GX(S/T)

Answer 39

N-acetyl-galactosamine

Answer 40

N-acetyl glucosamine

Answer 41

High-mannose Biantennary N-glycosylation

Answer 42

High-mannose N-glycosylation

Answer 43

Mannosylation

Answer 44

So they can be removed as markers for protein folding and transport

Answer 45

So the Golgi knows they're bound for the membrane

Answer 46

So the Golgi can degrade the protein as faulty

Answer 47

Because one of the three branches is removed, giving two 'antenna'

Answer 48

Because another branch is formed off the first one, giving two 'antenna'

Answer 49

Because proteins with this type of glycosylation act as receptor proteins with two antenna

Answer 50

Mannose is removed

Answer 51

Addition of N-acetyl neuraminic acids

Answer 52

Addition of glucose

Answer 53

Removal of N-acetyl glucosamine

Answer 54

Addition of a fucose to the GlcNac bound to the amino acid

Answer 55

It adds a date stamp to the cell- over time the NeuAc's fall off, which signals the protein for degredation

Answer 56

It adds a transport signal- depending on what is added or removed, proteins are directed to different areas by carrier proteins

Answer 57

It's quality control- the contortions required to add and remove all the sugars mean that the protein has folded properly

Answer 58

Because the immune system is programmed to ignore it, viral coat proteins can use it to hide the virus

Answer 59

Because NeuAc's can be toxic in high concentrations

Answer 60

Because the removal of mannose can cause the protein to misfold

Answer 61

CD4 receptor

Answer 62

CD8 receptor

Answer 63

B-lymphocyte receptors

Answer 64

It's only glycosylated on a very small binding site

Answer 65

It's only not glycosylated on a very small binding site

Answer 66

Which allows it to bind and invade

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Physical Modifications

Description

Resource summary

Question 1

Question 2

Question 3

Question 4

Question 5

Question 6

Question 7

Question 8

Question 9

Question 10

Question 11

Question 12

Question 13

Question 14

Question 15

Question 16

Question 17

Question 18

Question 19

Question 20

Question 21

Question 22

Question 23

Question 24

Question 25

Question 26

Question 27

Question 28

Question 29

Question 30

Question 31

Question 32

Question 33

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	Created by gina_evans0312 over 10 years ago