451493
Description
Quiz by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
almost 11 years ago
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Question 1
Question
What is the main problem of protein translocation?
Answer
-
Hydrophillic proteins must transverse two hydrophobic membranes and a hydrophillic space
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Proteins must be unfolded and refolded again
-
Proteins must pass through an extremely crowded cytoplasm
Question 2
Question
Proteins to be secreted directly after translation have a peptidase sequence at the C-terminus
Answer
- True
- False
Question 3
Question
Which of the following parts of the peptidase sequence are closest to the N-terminus?
Answer
-
The basic residues
-
The hydrophobic region
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Peptidase cleavage recognition site
Question 4
Question
There are 1-2 basic residues in the signal sequence, but the hydrophobic sequence is variable in length
Answer
- True
- False
Question 5
Question
When a protein is transcribed with the Peptidase signal site, what protein binds to its hydrophobic region?
Answer
-
Signal Recognition Protein
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Ftsy- a GTPase
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SecYEG- a bacterial pore
Question 6
Question
Ftsy transfers the protein into the pore
Answer
- True
- False
Question 7
Question
Which of the following provide the driving force for protein translocation across the membrane
Answer
-
Protonmotive force
-
FtsY's GTPase
-
Protein translation
Question 8
Question
What binds to the nascent polypeptide if Post-Translational Translocation takes place?
Answer
-
SecB
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SecA
-
SecC
Question 9
Question
Post-Translational Translocation sequences have a string of hydrophobic amino acids, same as in Translational Translocation
Answer
- True
- False
Question 10
Question
What is the role of Sec_ ?
Answer
-
To keep the protein in solution till it binds to SecA at the pore
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To fold the protein on its way to the periplasmic more
-
To stop the protein folding on its way to SecC
Question 11
Question
What forces are required to get a Post-Translational Translocation through the pore?
Answer
-
GTPase of FtsY
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ATP hydrolysis by SecB
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Protonmotive Force
Question 12
Question
Once inside the required membrane, what protein removes the peptide sequence?
Answer
-
Signal peptidase
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Signal lyase
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Signal Isomerase
Question 13
Question
The protein only folds after the signal sequence is cleaved
Answer
- True
- False
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