PSIO 404 Exam I

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Using for study.
Nhan Tran
Quiz by Nhan Tran, updated more than 1 year ago
Nhan Tran
Created by Nhan Tran over 8 years ago
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Resource summary

Question 1

Question
Which of the following is a covalent post-translational modification of signal proteins which is also ATP-independent?
Answer
  • Phosphorylation
  • GTP Hydrolysis
  • Nitrosylation
  • Oxidation

Question 2

Question
Which of the reactive oxygen species (ROS) is the most dangerous to cells?
Answer
  • Hydrogen peroxide (H2O2)
  • Superoxide anion radical (O2*-)
  • Hydroxyl radical (OH*)

Question 3

Question
When a signaling protein hydrolyzes a nucleotide triphosphate, order is produced. The resulting order is reflected in the formation of more protein-protein interactions.
Answer
  • True
  • False

Question 4

Question
For a generic switching reaction, which of the following statements is the most correct?
Answer
  • Switching a signal-processing protein "ON" always requires energy.
  • Switching a signal-processing protein "ON" or "OFF" requires energy, but only one direction for the switch must be linked to an energy-supplying reaction.
  • Switching a signal-processing protein "OFF" always requires energy.
  • Switching a signal-processing protein "ON" always requires energy, and switching a signal-processing protein "OFF" also always requires energy.

Question 5

Question
Which of the following terms refers to the way in which the binding of signal molecules alter conformation equilibrium for signal-processing proteins?
Answer
  • allostery
  • scaffolding
  • covalent interaction
  • adaptation

Question 6

Question
Which of the following is not a strategy for maintaining and improving stability in a signal-processing system?
Answer
  • noise filtering
  • redundancy
  • encoding
  • pattern generation
  • adaptation

Question 7

Question
Which of the following types of proteins acts to vastly speed up signal transduction by pre-assembling signaling proteins into a signaling complex?
Answer
  • noise-filtering proteins
  • proteins with one or more isoforms (alternatively-spliced proteins)
  • adaptor proteins
  • scaffold (scaffolding) proteins

Question 8

Question
Which statement is false?
Answer
  • The data-processing protein network ("brain") of a cell takes advantage of the modular design of proteins to link specific outputs to specific inputs.
  • The data-processing protein network ("brain") of a cell employs at least 4 mechanisms to maintain and improve stability.
  • The data-processing protein network ("brain") of a cell controls the availability and non-availability of interaction domains to govern how a signal is processed
  • The data-processing protein network ("brain") of a cell uses proteins as switching elements.
  • The data-processing protein network ("brain") of a cell rarely links short-range and long-range signaling during signal transduction.

Question 9

Question
Which family of proteins acts as unfoldases to dissociate protein-protein and protein-nucleic acid complexes?
Answer
  • the large (trimeric) G-protein family
  • the small G-protein family
  • the chaperone family
  • the AAA+ protein family

Question 10

Question
Chaperone proteins such as heat shock protein 90 (Hsp90) use the energy of _____ hydrolysis to enable misfolded steroid hormone receptors to go from native state (stable but non-functional state) to functional state.
Answer
  • ATP
  • glutathione
  • phosphoenol pyruvate (PEP)
  • GTP

Question 11

Question
For the phosphorylation switch, which of the following amino acids is not a common target of phosphorylation?
Answer
  • threonine (Thr)
  • lysine (Lys)
  • serine (Ser)
  • tyrosine (Tyr)

Question 12

Question
Which of the major subfamilies of protein kinases includes protein kinases that are activated by cAMP and cGMP?
Answer
  • the CMGC kinases
  • the Ste11 family
  • the AGC family
  • the Ca2+/calmodulin-dependent kinases

Question 13

Question
Which of the major subfamilies of protein kinases includes protein kinases that phosphorylate Ser and Thr amino acids in the neighborhood of Pro residues?
Answer
  • the CMGC kinases
  • the Ste11 family
  • the AGC family
  • the Ca2+/calmodulin-dependent kinases

Question 14

Question
Which of the major subfamilies of protein kinases includes mainly protein kinases that are constituents of MAP kinase modules?
Answer
  • the Ste11 family
  • the AGC family
  • the CMGC kinases
  • the Ca2+/calmodulin-dependent kinases
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