400577
Description
Quiz by thomasina413, updated more than 1 year ago
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Created by thomasina413
about 11 years ago
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Question 1
Question
A weak acid becomes more than 50% un-ionized following IV injection (blood pH = 7.4). The pKa of this weak acid could be...
Answer
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7.6
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7.4
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7.2
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1.5
Question 2
Question
When injected into the body, any of the local anesthetics used currently in clinical practice will be:
Answer
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less than 50% un-ionized
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more than 50% un-ionized
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50% un-ionized
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100% un-ionized
Question 3
Question
Sodium drug has pKa of 8.2. When injected into the blood, this drug will become:
Answer
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less than 50% un-ionized
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more than 50% un-ionized
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50% un-ionized
-
100% un-ionized
Question 4
Question
What situation most facilitates accumulation of local anesthetic by the fetus?
Answer
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maternal acidosis and fetal acidosis
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maternal acidosis and fetal alkalosis
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maternal alkalosis and fetal alkalosis
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maternal alkalosis and fetal acidosis
Question 5
Question
Potency is determined by what property(ies) of a local anesthetic?
Answer
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pKa
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lipid solubility
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protein binding
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both lipid solubility and protein binding
Question 6
Question
Speed of onset is determined by what property(ies) of a local anesthetic?
Answer
-
pKa
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lipid solubility
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protein binding
-
both lipid solubility and protein binding
Question 7
Question
Duration of action is determined by what property(ies) of a local anesthetic?
Answer
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pKa
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lipid solubility
-
protein binding
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both lipid solubility and protein binding
Question 8
Question
Local anesthetics work on which segment(s) of the neuron?
Answer
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axon only
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cell body and axon
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axon and nerve terminal
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cell body, axon and nerve terminal
Question 9
Question
Conduction block occurs when the...
Answer
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ionized form of the local anesthetic binds to the voltage-gated sodium channel outside the cell
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ionized form of the local anesthetic binds to the voltage-gated sodium channel inside the cell
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un-ionized form of the local anesthetic binds to the voltage-gated sodium channel outside the cell
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un-ionized form of the local anesthetic binds to the voltage-gated sodium channel inside the cell
Question 10
Question
You can make your own local anesthetic. If you want the local anesthetic to have a fast onset, you will want to have the local anesthetic have what pKa?
Answer
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2.3
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7.0
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7.4
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11.5
Question 11
Question
Injection of local anesthetic at which of the following sites is most likely to result in systemic toxicity?
Answer
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epidural space
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paracervical tissue
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intercostal muscles
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brachial plexus
Question 12
Question
Methemoglobinemia can occur if what local anesthetic is used?
Answer
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Tetracaine
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Prilocaine
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Ropivacaine
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Mepivacaine
Question 13
Question
What condition most prevents passage of local anesthetic from fetus to mom?
Answer
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maternal alkalosis
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maternal acidosis
-
fetal alkalosis
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fetal acidosis
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